ASMTL Antibody – Rabbit Polyclonal

Function: Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.

Tissue specificity: Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.

Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It represents a unique fusion product of 2 different genes of different evolutionary origin and function. The N-terminus is homologous to the bacterial maf/orfE genes and the C-terminus is homologous to ASMT. Exon duplication, exon shuffling and gene fusion seem to be common characteristics of the PAR1 region.

Sequence similarities: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.In the N-terminal section; belongs to the maf family.

Sequence caution: The sequence CAA75675.1 differs from that shown. Reason: Frameshift at position 616. The sequence CAA75676.1 differs from that shown. Reason: Frameshift at position 616.