Rabbit Anti-PPP1R13L Polyclonal Antibody – Cat# MBS649374

Western Blot analysis of PPP1R13L expression in transfected 293T cell line by PPP1R13L polyclonal antibody. Lane 1: PPP1R13L transfected lysate (89.1kD). Lane 2: Non-transfected lysate.

PPP1R13L Antibody – Rabbit Polyclonal

Name: PPP1R13L Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS649374
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649374

Inhibitor of apoptosis stimulating protein of p53 (iASPP) plays a central role in regulation of apoptosis and transcription via its interaction with NFkB and p53 proteins. At present, the iASPP gene is thought to encode three isoforms; isoform 1 is… More details

$970 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PPP1R13L, Polyclonal Antibody

Full Product Name

PPP1R13L (RelA-associated Inhibitor, Inhibitor of ASPP Protein, Protein iASPP, NFkB-interacting Protein 1, PPP1R13B-like Protein, IASPP, NKIP1, PPP1R13BL, RAI)

Product Gene Name

anti-PPP1R13L antibody

Product Synonym Names

Anti -PPP1R13L (RelA-associated Inhibitor, Inhibitor of ASPP Protein, Protein iASPP, NFkB-interacting Protein 1, PPP1R13B-like Protein, IASPP, NKIP1, PPP1R13BL, RAI)

Immunogen Sequence

MDSEAFQSAR DFLDMNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW SDSPAPPGPQ AGPPSRPPRY SSSSIPEPFG SRGSPRKAAT DGADTPFGRS ESAPTLHPYS PLSPKGRPSS PRTPLYLQPD AYGSLDRATS PRPRAFDGAG SSLGRAPSPR PGPGPLRQQG PPTPFDFLGR AGSPRGSPLA EGPQAFFSER GPSPRPPATA YDAPASAFGS SLLGSGGSAF APPLRAQDDL TLRRRPPKAW NESDLDVAYE KKPSQTASYE RLDVFARPAS PSLQLLPWRE SSLDGLGGTG KDNLTSATLP RNYKVSPLAS DRRSDAGSYR RSLGSAGPSG TLPRSWQPVS RIPMPPSSPQ PRGAPRQRPI PLSMIFKLQN AFWEHGASRA MLPGSPLFTR APPPKLQPQP QPQPQPQSQP QPQLPPQPQT QPQTPTPAPQ HPQQTWPPVN EGPPKPPTEL EPEPEIEGLL TPVLEAGDVD EGPVARPLSP TRLQPALPPE AQSVPELEEV ARVLAEIPRP LKRRGSMEQA PAVALPPTHK KQYQQIISRL FHRHGGPGPG GPEPELSPIT EGSEARAGPP APAPPAPIPP PAPSQSSPPE QPQSMEMRSV LRKAGSPRKA RRARLNPLVL LLDAALTGEL EVVQQAVKEM NDPSQPNEEG ITALHNAICG ANYSIVDFLI TAGANVNSPD SHGWTPLHCA ASCNDTVICM ALVQHGAAIF ATTLSDGATA FEKCDPYREG YADCATYLAD VEQSMGLMNS GAVYALWDYS AEFGDELSFR EGESVTVLRR DGPEETDWWW AALHGQEGYV PRNYFGLFPR VKPQRSKV

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human PPP1R13L.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

89,091 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (45882892..45909787, complement). Location: 19q13.32

OMIM

607463

3D Structure

ModBase 3D Structure for Q8WUF5

Immunogen

Full length human PPP1R13L, aa1-828 (AAH64913.1).

Product Categories/Family for anti-PPP1R13L antibody

Antibodies; Abs to Enzymes; Phosphatase

Applications Tested/Suitable for anti-PPP1R13L antibody

Western Blot (WB)

Application Notes for anti-PPP1R13L antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-PPP1R13L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPP1R13L purchase

MBS649374 is an antibody targeting PPP1R13L. Also known as PPP1R13L (RelA-associated Inhibitor, Inhibitor of ASPP Protein, Protein iASPP, NFkB-interacting Protein 1, PPP1R13B-like Protein, IASPP, NKIP1, PPP1R13BL, RAI). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP1R13L. It may not necessarily be applicable to this product.

NCBI GI #

33876266

NCBI GeneID

10848

NCBI Accession #

AAH01475.1

UniProt Primary Accession #

Q8WUF5

UniProt Secondary Accession #

Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q9Y290

UniProt Related Accession #

Q8WUF5

NCBI Official Full Name

PPP1R13L protein, partial

NCBI Official Synonym Full Names

protein phosphatase 1, regulatory subunit 13 like

NCBI Official Symbol

PPP1R13L

NCBI Official Synonym Symbols

RAI; RAI4; IASPP; NKIP1

UniProt Protein Name

RelA-associated inhibitor

UniProt Synonym Protein Names

Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein

Protein Family

RelA-associated inhibitor

UniProt Gene Name

PPP1R13L

UniProt Synonym Gene Names

IASPP; NKIP1; PPP1R13BL; RAI; Protein iASPP

UniProt Entry Name

IASPP_HUMAN

NCBI Protein Information

relA-associated inhibitor; protein iASPP; PPP1R13B-like protein; retinoic acid induced 4; inhibitor of ASPP protein; NFkB interacting protein 1; NFkB-interacting protein 1; inhibitor of apoptosis stimulating protein of p53; protein phosphatase 1, regulatory (inhibitor) subunit 13 like

NCBI Summary for PPP1R13L

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

UniProt Comments for PPP1R13L

Function: Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Ref.1 Ref.5 Ref.6 Ref.7

Subunit structure: Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73. Ref.1 Ref.5 Ref.6 Ref.7 Ref.15

Subcellular location: Cytoplasm. Nucleus. Note: Predominantly cytoplasmic but also nuclear. Ref.1 Ref.5

Tissue specificity: Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. Ref.5

Domain: Isoform 1 N-terminal region is required for cytoplasmic localization.

Sequence similarities: Belongs to the ASPP family.Contains 2 ANK repeats.Contains 1 SH3 domain.

Sequence caution: The sequence AAD27004.1 differs from that shown. Reason: Frameshift at positions 439, 483, 562 and 591. The sequence AAD27005.1 differs from that shown. Reason: Frameshift at positions 483, 562 and 591. The sequence AAD27005.1 differs from that shown. Reason: Probable cloning artifact.

Research Articles on PPP1R13L

1. PPP1R13L and CD3EAP variants may be associated with lung cancer risk in nonsmoking Chinese women.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPP1R13L antibody

Reference Product	PubMed Publications
CD3EAP antibody	>14 publications with PPP1R13L and CD3EAP
RELA antibody	>11 publications with PPP1R13L and RELA
TP53 antibody	>8 publications with PPP1R13L and TP53
TP63 antibody	>3 publications with PPP1R13L and TP63
SP1 antibody	>2 publications with PPP1R13L and SP1

Pathways associated with anti-PPP1R13L antibody

Products by Pathway	Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram
TNF-alpha/NF-kB Signaling Pathway antibodies	TNF-alpha/NF-kB Signaling Pathway Diagram
P53 Pathway antibodies	P53 Pathway Diagram

Diseases associated with anti-PPP1R13L antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>46 publications with PPP1R13L and Neoplasms
Lung Diseases Antibodies	>13 publications with PPP1R13L and Lung Diseases
Lung Neoplasms Antibodies	>12 publications with PPP1R13L and Lung Neoplasms
Breast Neoplasms Antibodies	>10 publications with PPP1R13L and Breast Neoplasms
Cardiovascular Diseases Antibodies	>8 publications with PPP1R13L and Cardiovascular Diseases
Liver Diseases Antibodies	>4 publications with PPP1R13L and Liver Diseases
Neoplasm Metastasis Antibodies	>4 publications with PPP1R13L and Neoplasm Metastasis
Cell Transformation, Neoplastic Antibodies	>4 publications with PPP1R13L and Cell Transformation, Neoplastic
Hematologic Diseases Antibodies	>3 publications with PPP1R13L and Hematologic Diseases
Congenital Abnormalities Antibodies	>3 publications with PPP1R13L and Congenital Abnormalities

Organs/Tissues associated with anti-PPP1R13L antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>15 publications with PPP1R13L and Lung
Skin Antibodies	>5 publications with PPP1R13L and Skin
Liver Antibodies	>4 publications with PPP1R13L and Liver
Placenta Antibodies	>3 publications with PPP1R13L and Placenta
Heart Antibodies	>3 publications with PPP1R13L and Heart
Embryonic Tissue Antibodies	>3 publications with PPP1R13L and Embryonic Tissue
Brain Antibodies	>2 publications with PPP1R13L and Brain
Prostate Antibodies	>2 publications with PPP1R13L and Prostate
Bone Antibodies	>2 publications with PPP1R13L and Bone
Eye Antibodies	>1 publications with PPP1R13L and Eye