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MLXIP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649375

MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000 [PubMed 11073985]). More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MLXIP, Polyclonal Antibody
Full Product Name
MLXIP, NT (MLXIP, BHLHE36, KIAA0867, MIR, MONDOA, MLX-interacting protein, Class E basic helix-loop-helix protein 36, Transcriptional activator MondoA)
Product Gene Name
anti-MLXIP antibody
Product Synonym Names
Anti -MLXIP, NT (MLXIP, BHLHE36, KIAA0867, MIR, MONDOA, MLX-interacting protein, Class E basic helix-loop-helix protein 36, Transcriptional activator MondoA)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
101,185 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (122516652..122517172). Location: 12q24.31
OMIM
608090
3D Structure
ModBase 3D Structure for Q9HAP2
Immunogen
MLXIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the N-terminal region of human MLXIP.

Product Categories/Family for anti-MLXIP antibody

Antibodies; Abs to KIAA; orf
Applications Tested/Suitable for anti-MLXIP antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MLXIP antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

Western Blot (WB) of anti-MLXIP antibody

MLXIP Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the MLXIP antibody detected the MLXIP protein (arrow).
Rabbit Anti-MLXIP Polyclonal Antibody – Cat# MBS649375

Immunohistochemistry (IHC) of anti-MLXIP antibody

MLXIP antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MLXIP antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-MLXIP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS649375

Other Notes

Small volumes of anti-MLXIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MLXIP purchase

MBS649375 is an antibody targeting MLXIP. Also known as MLXIP, NT (MLXIP, BHLHE36, KIAA0867, MIR, MONDOA, MLX-interacting protein, Class E basic helix-loop-helix protein 36, Transcriptional activator MondoA). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MLXIP. It may not necessarily be applicable to this product.

NCBI GI #
111955326
NCBI GeneID
22877
NCBI Accession #
NP_055753.3
UniProt Primary Accession #
Q9HAP2
UniProt Secondary Accession #
O94945; Q7LC47; Q8IXP1; Q8TAH9; Q8WVQ0; Q8WYA5; A7MBN0
UniProt Related Accession #
Q9HAP2
GenBank Nucleotide #
NM_014938.4
NCBI Official Full Name
MLX-interacting protein
NCBI Official Synonym Full Names
MLX interacting protein
NCBI Official Symbol
MLXIP
NCBI Official Synonym Symbols
MIR; MONDOA; bHLHe36
UniProt Protein Name
MLX-interacting protein
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 36; bHLHe36; Transcriptional activator MondoA
Protein Family
MLX-interacting protein
UniProt Gene Name
MLXIP
UniProt Synonym Gene Names
BHLHE36; KIAA0867; MIR; MONDOA; bHLHe36
UniProt Entry Name
MLXIP_HUMAN
NCBI Protein Information
MLX-interacting protein; MondoA; Mlx interactor; transcriptional activator MondoA; class E basic helix-loop-helix protein 36

UniProt Comments for MLXIP

Function: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. Ref.5 Ref.6

Subunit structure: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MLX.

Subcellular location: Cytoplasm. Nucleus. Mitochondrion outer membrane. Note: Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. Ref.5 Ref.6

Tissue specificity: Widely expressed in adult tissues. Most abundant in skeletal muscle. Ref.1

Sequence similarities: Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence caution: The sequence BAA74890.2 differs from that shown. Reason: Erroneous initiation.
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Research Articles on MLXIP

1. Suppression of Txnip by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MLXIP antibody

 Reference Product  PubMed Publications
 MLX antibody  >1 publications with MLXIP and MLX

Pathways associated with anti-MLXIP antibody

 Products by Pathway  Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram

Diseases associated with anti-MLXIP antibody

 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >1 publications with MLXIP and Lymphoma
 Hypertension Antibodies  >1 publications with MLXIP and Hypertension
 Abnormalities, Drug-Induced Antibodies  >1 publications with MLXIP and Abnormalities, Drug-Induced
 Inflammation Antibodies  >1 publications with MLXIP and Inflammation

Organs/Tissues associated with anti-MLXIP antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with MLXIP and Heart
 Connective Tissue Antibodies  >1 publications with MLXIP and Connective Tissue
 Ascites Antibodies  >1 publications with MLXIP and Ascites
 Blood Antibodies  >1 publications with MLXIP and Blood
 Adipose Tissue Antibodies  >1 publications with MLXIP and Adipose Tissue
 Muscle Antibodies  >1 publications with MLXIP and Muscle
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