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CTSL2 (CTSV) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649451

Cathepsin V, also known as Cathepsin L2 and Cathepsin U, is a cysteine protease of the papain family. It is expressed as a proenzyme in lysosomes, which can be autocatalytically converted to the mature form at pH 4.0. Cathepsin V is specifically expressed in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CTSL2 (CTSV), Polyclonal Antibody
Full Product Name
CTSL2, ID (Cathepsin V, Cathepsin L2, Cathepsin U, Cathepsin V, CATL2, CTSU, CTSV, UNQ268/PRO305)
Product Gene Name
anti-CTSV antibody
Product Synonym Names
Anti -CTSL2, ID (Cathepsin V, Cathepsin L2, Cathepsin U, Cathepsin V, CATL2, CTSU, CTSV, UNQ268/PRO305)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CTSL2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
37,329 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (99791959..99801925, complement). Location: 9q22.2
OMIM
603308
3D Structure
ModBase 3D Structure for O60911
Immunogen
Synthetic peptide corresponding to human CATL2.

Product Categories/Family for anti-CTSV antibody

Antibodies; Abs to Cathepsin
Applications Tested/Suitable for anti-CTSV antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CTSV antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA: 1:20,000
Western Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Immunohistochemistry (IHC) of anti-CTSV antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CTSV Polyclonal Antibody – Cat# MBS649451

Western Blot (WB) of anti-CTSV antibody

Western blot analysis of extracts from 293/COS cells, treated with etoposide 25uM 1h, using CATL2 (Cleaved-Leu114) Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-CTSV Polyclonal Antibody, Western Blot (WB) – Cat# MBS649451

Other Notes

Small volumes of anti-CTSV antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTSV purchase

MBS649451 is an antibody targeting CTSV. Also known as CTSL2, ID (Cathepsin V, Cathepsin L2, Cathepsin U, Cathepsin V, CATL2, CTSU, CTSV, UNQ268/PRO305). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CTSV. It may not necessarily be applicable to this product.

NCBI GI #
320118898
NCBI GeneID
1515
NCBI Accession #
NP_001188504.1
UniProt Primary Accession #
O60911
UniProt Secondary Accession #
O60233; Q2TB86; Q5T1U0
UniProt Related Accession #
O60911
GenBank Nucleotide #
NM_001201575.1
NCBI Official Full Name
cathepsin L2 preproprotein
NCBI Official Synonym Full Names
cathepsin V
NCBI Official Symbol
CTSV
NCBI Official Synonym Symbols
CTSU; CATL2; CTSL2
UniProt Protein Name
Cathepsin L2
UniProt Synonym Protein Names
Cathepsin U; Cathepsin V
UniProt Gene Name
CTSV
UniProt Synonym Gene Names
CATL2; CTSL2; CTSU
UniProt Entry Name
CATL2_HUMAN
NCBI Protein Information
cathepsin L2; cathepsin U; cathepsin L2, preproprotein

NCBI Summary for CTSV

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]
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UniProt Comments for CTSV

Function: Cysteine protease. May have an important role in corneal physiology. Ref.2 Ref.3

Catalytic activity: The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec). Ref.3

Subcellular location: Lysosome

Potential.

Tissue specificity: Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin. Ref.1 Ref.2 Ref.3

Sequence similarities: Belongs to the peptidase C1 family.
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Research Articles on CTSV

1. Cathepsin V expression contributes to the development of dermal fibrosis and vasculopathy in systemic sclerosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CTSV antibody

 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram

Diseases associated with anti-CTSV antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with CTSV and Kidney Diseases
 Fibrosis Antibodies  >1 publications with CTSV and Fibrosis

Organs/Tissues associated with anti-CTSV antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >4 publications with CTSV and Skin
 Muscle Antibodies  >1 publications with CTSV and Muscle
 Bladder Antibodies  >1 publications with CTSV and Bladder
 Pancreas Antibodies  >1 publications with CTSV and Pancreas
 Kidney Antibodies  >1 publications with CTSV and Kidney
 Thymus Antibodies  >1 publications with CTSV and Thymus
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