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Kallikrein 6 (KLK1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649453

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK6 enzyme is… More details

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Product Overview

Online Datasheet in PDF
Product Name
Kallikrein 6 (KLK1), Polyclonal Antibody
Full Product Name
Kallikrein 6, ID (KLK6, PRSS18, PRSS9, Kallikrein-6, Neurosin, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme)
Product Gene Name
anti-KLK1 antibody
Product Synonym Names
Anti -Kallikrein 6, ID (KLK6, PRSS18, PRSS9, Kallikrein-6, Neurosin, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
28,890 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (51322402..51327043, complement). Location: 19q13.3
OMIM
147910
3D Structure
ModBase 3D Structure for P06870
Immunogen
Kallikrein 6 Antibody antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134~164 amino acids from the central region of human KLK6.

Product Categories/Family for anti-KLK1 antibody

Antibodies; Abs to Kallikrein
Applications Tested/Suitable for anti-KLK1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-KLK1 antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Immunohistochemistry: 1:10-50
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-KLK1 antibody

Western blot analysis of KLK6 (arrow) using rabbit polyclonal KLK6 Antibody (L141) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the KLK6 gene.
Rabbit Anti-KLK1 Polyclonal Antibody – Cat# MBS649453

Immunohistochemistry (IHC) of anti-KLK1 antibody

Kallikrein 6(KLK6) Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Kallikrein 6(KLK6) Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-KLK1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS649453

Flow Cytometry (FC/FACS) of anti-KLK1 antibody

Kallikrein 6 (KLK6) Antibody (Center) Antibody flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-KLK1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS649453

Other Notes

Small volumes of anti-KLK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLK1 purchase

MBS649453 is an antibody targeting KLK1. Also known as Kallikrein 6, ID (KLK6, PRSS18, PRSS9, Kallikrein-6, Neurosin, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KLK1. It may not necessarily be applicable to this product.

NCBI GI #
386843
NCBI GeneID
3816
NCBI Accession #
AAA59201.1
UniProt Primary Accession #
P06870
UniProt Secondary Accession #
Q66US9; Q86U61; Q8TCV8; Q9BS53; Q9NQU4; Q9UD19; Q9UMJ1
UniProt Related Accession #
P06870
NCBI Official Full Name
kallikrein, partial
NCBI Official Synonym Full Names
kallikrein 1
NCBI Official Symbol
KLK1
NCBI Official Synonym Symbols
hK1; KLKR; Klk6
UniProt Protein Name
Kallikrein-1
UniProt Synonym Protein Names
Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein
Protein Family
Blarinasin
UniProt Gene Name
KLK1
UniProt Entry Name
KLK1_HUMAN
NCBI Protein Information
kallikrein-1; tissue kallikrein; glandular kallikrein 1; kallikrein serine protease 1; kallikrein 1, renal/pancreas/salivary; kidney/pancreas/salivary gland kallikrein

NCBI Summary for KLK1

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
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UniProt Comments for KLK1

Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activity: Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Tissue specificity: Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. Ref.4

Post-translational modification: The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In Ref.13, GalNAc was detected with the corresponding peptides but not located.

Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.
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Research Articles on KLK1

1. Unexpectedly, elevated KLK1 expression and excretion is found in patients with established or incipient acute kidney injury.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KLK1 antibody

 Reference Product  PubMed Publications
 IL4I1 antibody  >1 publications with KLK1 and IL4I1

Pathways associated with anti-KLK1 antibody

 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram

Diseases associated with anti-KLK1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >25 publications with KLK1 and Neoplasms
 Vascular Diseases Antibodies  >17 publications with KLK1 and Vascular Diseases
 Kidney Diseases Antibodies  >15 publications with KLK1 and Kidney Diseases
 Hypertension Antibodies  >14 publications with KLK1 and Hypertension
 Brain Diseases Antibodies  >8 publications with KLK1 and Brain Diseases
 Inflammation Antibodies  >7 publications with KLK1 and Inflammation
 Lung Diseases Antibodies  >6 publications with KLK1 and Lung Diseases
 Fibrosis Antibodies  >5 publications with KLK1 and Fibrosis
 Heart Diseases Antibodies  >4 publications with KLK1 and Heart Diseases
 Renal Insufficiency Antibodies  >3 publications with KLK1 and Renal Insufficiency

Organs/Tissues associated with anti-KLK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >24 publications with KLK1 and Kidney
 Skin Antibodies  >18 publications with KLK1 and Skin
 Heart Antibodies  >6 publications with KLK1 and Heart
 Salivary Gland Antibodies  >5 publications with KLK1 and Salivary Gland
 Pancreas Antibodies  >4 publications with KLK1 and Pancreas
 Intestine Antibodies  >2 publications with KLK1 and Intestine
 Ovary Antibodies  >2 publications with KLK1 and Ovary
 Thyroid Antibodies  >2 publications with KLK1 and Thyroid
 Bone Antibodies  >1 publications with KLK1 and Bone
 Uncharacterized Tissue Antibodies  >1 publications with KLK1 and Uncharacterized Tissue
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