Mouse Anti-TNRC6B Monoclonal Antibody – Cat# MBS649459

Western Blot detection against Immunogen (37kD).

TNRC6B Antibody – Mouse Monoclonal

Name: TNRC6B Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS649459
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649459

MBS649459 is an antibody targeting TNRC6B. Also known as TNRC6B (Trinucleotide Repeat-containing Gene 6B Protein, KIAA1093). Reactive in Human. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TNRC6B, Monoclonal Antibody

Full Product Name

TNRC6B (Trinucleotide Repeat-containing Gene 6B Protein, KIAA1093)

Product Gene Name

anti-TNRC6B antibody

Product Synonym Names

Anti -TNRC6B (Trinucleotide Repeat-containing Gene 6B Protein, KIAA1093)

Immunogen Sequence

ECNLGVWKSD PKAKSVQSSN STTENNNGLG NWRNVSGQDR IGPGSGFSNF NPNSNPSAWP ALVQEGTSRK GALETDNSNS SAQVSTVGQT SREQQSKMEN

Clonality

Monoclonal

Isotype

IgG2a,k

Clone Number

4B11

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human TNRC6B.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

194,002 Da

Chromosome Location

Chromosome: 22; NC_000022.10 (40440046..40731812). Location: 22q13.1

OMIM

610740

3D Structure

ModBase 3D Structure for Q9UPQ9

Immunogen

Partial recombinant corresponding to aa253-352 from TNRC6B (NP_055903) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-TNRC6B antibody

Antibodies; Abs to RNA Processing

Applications Tested/Suitable for anti-TNRC6B antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-TNRC6B antibody

Suitable for use in ELISA and Western Blot.

Other Notes

Small volumes of anti-TNRC6B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNRC6B. It may not necessarily be applicable to this product.

NCBI GI #

20306948

NCBI GeneID

23112

NCBI Accession #

AAH28626.1

UniProt Primary Accession #

Q9UPQ9

UniProt Secondary Accession #

Q5TH52; Q8TBX2; B0QY73; B0QY78; B4DGC0

UniProt Related Accession #

Q9UPQ9

NCBI Official Full Name

TNRC6B protein

NCBI Official Synonym Full Names

trinucleotide repeat containing 6B

NCBI Official Symbol

TNRC6B

UniProt Protein Name

Trinucleotide repeat-containing gene 6B protein

Protein Family

Trinucleotide repeat-containing gene 6B protein

UniProt Gene Name

TNRC6B

UniProt Synonym Gene Names

KIAA1093

UniProt Entry Name

TNR6B_HUMAN

NCBI Protein Information

trinucleotide repeat-containing gene 6B protein

UniProt Comments for TNRC6B

Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Ref.7 Ref.10 Ref.11 Ref.16

Subunit structure: Interacts with AGO1, AGO2, AGO3 and AGO4. Interacts with CNOT1; the interaction mediates the association with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex. Ref.7 Ref.8 Ref.10 Ref.11 Ref.12 Ref.16 Ref.17

Subcellular location: Cytoplasm › P-body. Note: Mammalian P-bodies are also known as GW bodies (GWBs). Ref.7 Ref.10

Sequence similarities: Belongs to the GW182 family.Contains 1 RRM (RNA recognition motif) domain.

Sequence caution: The sequence BAA83045.2 differs from that shown. Reason: Erroneous initiation.

Research Articles on TNRC6B

1. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNRC6B antibody

Reference Product	PubMed Publications
EIF2C2 antibody	>7 publications with TNRC6B and EIF2C2
EIF2C1 antibody	>4 publications with TNRC6B and EIF2C1
MOV10 antibody	>3 publications with TNRC6B and MOV10
TNRC6C antibody	>3 publications with TNRC6B and TNRC6C
TNRC6A antibody	>2 publications with TNRC6B and TNRC6A
EIF2C4 antibody	>1 publications with TNRC6B and EIF2C4
DICER1 antibody	>1 publications with TNRC6B and DICER1
PABPC1 antibody	>1 publications with TNRC6B and PABPC1

Pathways associated with anti-TNRC6B antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies	Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
GAB1 Signalosome Pathway antibodies	GAB1 Signalosome Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram

Diseases associated with anti-TNRC6B antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with TNRC6B and Neoplasms
Genital Diseases, Male Antibodies	>2 publications with TNRC6B and Genital Diseases, Male
Prostatic Diseases Antibodies	>2 publications with TNRC6B and Prostatic Diseases
Carcinoma Antibodies	>2 publications with TNRC6B and Carcinoma
Liver Diseases Antibodies	>1 publications with TNRC6B and Liver Diseases
Liver Neoplasms Antibodies	>1 publications with TNRC6B and Liver Neoplasms

Organs/Tissues associated with anti-TNRC6B antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>2 publications with TNRC6B and Prostate
Liver Antibodies	>1 publications with TNRC6B and Liver
Heart Antibodies	>1 publications with TNRC6B and Heart
Brain Antibodies	>1 publications with TNRC6B and Brain