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GNG3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649497

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GNG3, Monoclonal Antibody
Full Product Name
GNG3 (Guanine Nucleotide-binding Protein G(I)/G(S)/G(O) Subunit gamma-3, GNGT3)
Product Gene Name
anti-Gng3 antibody
Product Synonym Names
Anti -GNG3 (Guanine Nucleotide-binding Protein G(I)/G(S)/G(O) Subunit gamma-3, GNGT3)
Immunogen Sequence
MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC EDPLITPVPT SENPFREKKF FCALL
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
1E10-1B5
Host
Mouse
Species Reactivity
Human, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human GNG3. Species Crossreactivity: rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
8,305 Da
Chromosome Location
Chromosome: 19; NC_000085.6 (8836929..8839246, complement). Location: 19 A; 19 5.76 cM
3D Structure
ModBase 3D Structure for P63216
Immunogen
Full length recombinant corresponding to aa1-75 from human GNG3 (AAH15563) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-Gng3 antibody

Antibodies; Abs to G Proteins
Applications Tested/Suitable for anti-Gng3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Gng3 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-Gng3 antibody

Western Blot detection against Immunogen (33.99kD).
Mouse Anti-GNG3 Monoclonal Antibody – Cat# MBS649497

Western Blot (WB) of anti-Gng3 antibody

GNG3 monoclonal antibody. Western Blot analysis of GNG3 expression in rat brain.
Mouse Anti-GNG3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS649497

Testing Data of anti-Gng3 antibody

Detection limit for recombinant GST tagged GNG3 is ~1ng/ml as a capture antibody.
Mouse Anti-GNG3 Monoclonal Antibody, Testing Data – Cat# MBS649497

Other Notes

Small volumes of anti-Gng3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gng3 purchase

MBS649497 is an antibody targeting Gng3. Also known as GNG3 (Guanine Nucleotide-binding Protein G(I)/G(S)/G(O) Subunit gamma-3, GNGT3). Reactive in Human, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Gng3. It may not necessarily be applicable to this product.

NCBI GI #
6754022
NCBI GeneID
14704
NCBI Accession #
NP_034446.1
UniProt Primary Accession #
P63216
UniProt Secondary Accession #
P29798; Q61014
UniProt Related Accession #
P63216
GenBank Nucleotide #
NM_010316.3
NCBI Official Full Name
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
NCBI Official Synonym Full Names
guanine nucleotide binding protein (G protein), gamma 3
NCBI Official Symbol
Gng3
UniProt Protein Name
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
UniProt Gene Name
Gng3
UniProt Synonym Gene Names
Gngt3
UniProt Entry Name
GBG3_MOUSE
NCBI Protein Information
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3; guanine nucleotide binding protein (G protein), gamma 3 subunit

UniProt Comments for Gng3

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure: G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side

Potential.

Tissue specificity: Abundantly expressed in brain. Low levels in testis.

Sequence similarities: Belongs to the G protein gamma family.
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Research Articles on Gng3

1. Synergistic roles for G-protein gamma3 and gamma7 subtypes in seizure susceptibility as revealed in double knock-out mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Gng3 antibody

 Reference Product  PubMed Publications
 Gng7 antibody  >2 publications with Gng3 and Gng7

Pathways associated with anti-Gng3 antibody

 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram

Diseases associated with anti-Gng3 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with Gng3 and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with Gng3 and Nervous System Diseases
 Weight Gain Antibodies  >1 publications with Gng3 and Weight Gain
 Weight Loss Antibodies  >1 publications with Gng3 and Weight Loss
 Necrosis Antibodies  >1 publications with Gng3 and Necrosis

Organs/Tissues associated with anti-Gng3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with Gng3 and Brain
 Thyroid Antibodies  >1 publications with Gng3 and Thyroid
 Eye Antibodies  >1 publications with Gng3 and Eye
 Embryonic Tissue Antibodies  >1 publications with Gng3 and Embryonic Tissue
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