DGAT2 Antibody – Rabbit Polyclonal

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides

By similarity. Functions also as an acyl-CoA retinol acyltransferase (ARAT).

Catalytic activity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. Ref.9Acyl-CoA + retinol = CoA + retinyl ester. Ref.9

Enzyme regulation: Inhibited by niacin

By similarity.

Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis.

Subunit structure: Forms multimeric complexes consisting of several DGAT2 subunits

By similarity.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet

By similarity Ref.2.

Tissue specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. Ref.1 Ref.2

Sequence similarities: Belongs to the diacylglycerol acyltransferase family.

Sequence caution: The sequence BAD38635.1 differs from that shown. Reason: Erroneous initiation. The sequence CAD38961.1 differs from that shown. Reason: Erroneous initiation.