CREB3L1 Antibody – Goat Polyclonal

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE

By similarity. Ref.1

Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein Ref.1 Ref.4. Processed cyclic AMP-responsive element-binding protein 3-like protein 1: Nucleus. Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. Ref.1 Ref.4

Tissue specificity: Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain. Ref.1

Post-translational modification: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.

Sequence similarities: Belongs to the bZIP family. ATF subfamily.Contains 1 bZIP (basic-leucine zipper) domain.

Sequence caution: The sequence BAC11681.1 differs from that shown. Reason: Erroneous initiation.