SIN3A Antibody – Rabbit Polyclonal

Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Ref.2 Ref.5 Ref.12

Subunit structure: Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase

By similarity. Interacts with BAZ2A, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Ref.2 Ref.5 Ref.7 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.21 Ref.23

Subcellular location: Nucleus. Nucleus › nucleolus. Note: Recruited to the nucleolus by SAP30L

By similarity.

Tissue specificity: Widely expressed. Highest levels in testis, lung and thymus.

Post-translational modification: SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2

By similarity.

Sequence similarities: Contains 3 PAH (paired amphipathic helix) domains.

Sequence caution: The sequence AAB01610.1 differs from that shown. Reason: The cDNA contains an internal 15bp tandem duplication.The sequence AAH52716.1 differs from that shown. Reason: Probable cloning artifact leading to an internal deletion.The sequence AAH53385.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence BAD90217.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.