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FXYD Domain Containing Ion Transport Regulator 2 (FXYD2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649576

MBS649576 is an antibody targeting FXYD2. Also known as FXYD Domain Containing Ion Transport Regulator 2 (FXYD2, ATP1C, ATP1G1, HOMG2, MGC12372, Sodium/potassium-transporting ATPase Subunit gamma, Na(+)/K(+) ATPase Subunit gamma, Sodium Pump gamma Chain).… More details

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Product Overview

Online Datasheet in PDF
Product Name
FXYD Domain Containing Ion Transport Regulator 2 (FXYD2), Monoclonal Antibody
Full Product Name
FXYD Domain Containing Ion Transport Regulator 2 (FXYD2, ATP1C, ATP1G1, HOMG2, MGC12372, Sodium/potassium-transporting ATPase Subunit gamma, Na(+)/K(+) ATPase Subunit gamma, Sodium Pump gamma Chain)
Product Gene Name
anti-FXYD2 antibody
Product Synonym Names
Anti -FXYD Domain Containing Ion Transport Regulator 2 (FXYD2, ATP1C, ATP1G1, HOMG2, MGC12372, Sodium/potassium-transporting ATPase Subunit gamma, Na(+)/K(+) ATPase Subunit gamma, Sodium Pump gamma Chain)
Immunogen Sequence
MDRWYLGGSP KGDVDPFYYD YETVRNGGLI FAGLAFIVGL LILLSRRFRC GGNKKRRQIN EDEP
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
1C3-B3
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human FXYD2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
7,283 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (117690790..117699408, complement). Location: 11q23
OMIM
154020
3D Structure
ModBase 3D Structure for P54710
Immunogen
Full length recombinant corresponding to aa1-64 from human FXYD2 (AAH05302.1) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-FXYD2 antibody

Antibodies; Abs to Enzymes; ATPase
Applications Tested/Suitable for anti-FXYD2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FXYD2 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml

Western Blot (WB) of anti-FXYD2 antibody

Western Blot detection against Immunogen (32.78kD).
Mouse Anti-FXYD2 Monoclonal Antibody – Cat# MBS649576

Western Blot (WB) of anti-FXYD2 antibody

FXYD2 monoclonal antibody Western Blot analysis of FXYD2 expression in Jurkat.
Mouse Anti-FXYD2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS649576

Immunohistochemistry (IHC) of anti-FXYD2 antibody

Immunoperoxidase of monoclonal antibody to FXYD2 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3ug/ml].
Mouse Anti-FXYD2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS649576

Other Notes

Small volumes of anti-FXYD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FXYD2. It may not necessarily be applicable to this product.

NCBI GI #
15342034
NCBI GeneID
486
NCBI Accession #
AAH13289.1
UniProt Primary Accession #
P54710
UniProt Secondary Accession #
Q15332; Q53YC1; Q9GZP3; Q9GZQ7
UniProt Related Accession #
P54710
NCBI Official Full Name
FXYD domain containing ion transport regulator 2
NCBI Official Synonym Full Names
FXYD domain containing ion transport regulator 2
NCBI Official Symbol
FXYD2
NCBI Official Synonym Symbols
HOMG2; ATP1G1
UniProt Protein Name
Sodium/potassium-transporting ATPase subunit gamma
UniProt Synonym Protein Names
FXYD domain-containing ion transport regulator 2; Sodium pump gamma chain
Protein Family
Sodium/potassium-transporting ATPase
UniProt Gene Name
FXYD2
UniProt Synonym Gene Names
ATP1C; ATP1G1; Na(+)/K(+) ATPase subunit gamma
UniProt Entry Name
ATNG_HUMAN
NCBI Protein Information
sodium/potassium-transporting ATPase subunit gamma; sodium pump gamma chain; Na(+)/K(+) ATPase subunit gamma; ATPase, Na+/K+ transporting, gamma 1 polypeptide

NCBI Summary for FXYD2

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]
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UniProt Comments for FXYD2

Function: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

Subunit structure: Composed of three subunits: alpha (catalytic), beta and gamma.

Subcellular location: Membrane; Single-pass type III membrane protein

Potential.

Tissue specificity: Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron epithelial cells.

Involvement in disease: Hypomagnesemia 2 (HOMG2) [MIM:154020]: A disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.3

Sequence similarities: Belongs to the FXYD family.

Sequence caution: The sequence AAB09425.1 differs from that shown. Reason: Frameshift at position 12. The sequence CAA60152.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.
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Research Articles on FXYD2

1. findings confirm the presence of an FXYD2 peptide in the crab gill Na,K-ATPase and demonstrate that this peptide plays an important role in regulating enzyme activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FXYD2 antibody

 Reference Product  PubMed Publications
 HNF1B antibody  >4 publications with FXYD2 and HNF1B
 CLDN16 antibody  >2 publications with FXYD2 and CLDN16
 ATP1A1 antibody  >2 publications with FXYD2 and ATP1A1
 ATP1B1 antibody  >1 publications with FXYD2 and ATP1B1

Pathways associated with anti-FXYD2 antibody

 Products by Pathway  Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram

Diseases associated with anti-FXYD2 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >8 publications with FXYD2 and Kidney Diseases
 Magnesium Deficiency Antibodies  >5 publications with FXYD2 and Magnesium Deficiency
 Hypertension Antibodies  >2 publications with FXYD2 and Hypertension
 Mitochondrial Diseases Antibodies  >1 publications with FXYD2 and Mitochondrial Diseases
 Nervous System Diseases Antibodies  >1 publications with FXYD2 and Nervous System Diseases
 Hypertrophy Antibodies  >1 publications with FXYD2 and Hypertrophy
 Neurodegenerative Diseases Antibodies  >1 publications with FXYD2 and Neurodegenerative Diseases
 Immune System Diseases Antibodies  >1 publications with FXYD2 and Immune System Diseases
 Neoplasms Antibodies  >1 publications with FXYD2 and Neoplasms
 Hyperplasia Antibodies  >1 publications with FXYD2 and Hyperplasia

Organs/Tissues associated with anti-FXYD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >51 publications with FXYD2 and Kidney
 Muscle Antibodies  >10 publications with FXYD2 and Muscle
 Blood Antibodies  >9 publications with FXYD2 and Blood
 Heart Antibodies  >7 publications with FXYD2 and Heart
 Brain Antibodies  >6 publications with FXYD2 and Brain
 Pancreas Antibodies  >5 publications with FXYD2 and Pancreas
 Intestine Antibodies  >5 publications with FXYD2 and Intestine
 Embryonic Tissue Antibodies  >3 publications with FXYD2 and Embryonic Tissue
 Liver Antibodies  >2 publications with FXYD2 and Liver
 Connective Tissue Antibodies  >2 publications with FXYD2 and Connective Tissue
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