COL19A1 Antibody – Rabbit Polyclonal

This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008]

Function: May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. Ref.8

Subunit structure: Oligomer; disulfide-linked. Ref.8

Subcellular location: Secreted › extracellular space › extracellular matrix

By similarity.

Tissue specificity: Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord. Ref.8

Domain: The numerous interruptions in the triple helix may make this molecule either elastic or flexible. Ref.8

Post-translational modification: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Sequence similarities: Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.Contains 11 collagen-like domains.Contains 1 laminin G-like domain.

Sequence caution: The sequence CAC12699.3 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI42319.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI42496.2 differs from that shown. Reason: Erroneous gene model prediction.