SLC22A17 Antibody – Goat Polyclonal

Function: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note: Upon LCN2-binding, it is internalized. Ref.1

Tissue specificity: Expressed in brain.

Induction: Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway. Ref.6 Ref.7

Sequence similarities: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Sequence caution: The sequence CAC01119.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC17762.1 differs from that shown. Reason: Erroneous initiation.