SEMA6D Antibody – Rabbit Polyclonal

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]

Function: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein Ref.1. Isoform 2: Cell membrane; Single-pass type I membrane protein Ref.1. Isoform 3: Cell membrane; Single-pass type I membrane protein Ref.1. Isoform 4: Cell membrane; Single-pass type I membrane protein Ref.1. Isoform 5: Cell membrane; Single-pass type I membrane protein Ref.1. Isoform 7: Cytoplasm Ref.1.

Sequence similarities: Belongs to the semaphorin family.Contains 1 PSI domain.Contains 1 Sema domain.

Sequence caution: The sequence BAA96003.2 differs from that shown. Reason: Erroneous initiation.