BATF3 Antibody – Mouse Polyclonal

Function: AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens. Ref.3 Ref.4 Ref.6

Subunit structure: Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.

Subcellular location: Nucleus

By similarity.

Tissue specificity: Highly expressed in CD8-alpha+ classical dendritic cells (cDCs), with low to absent expression in other immune cells and non-immune tissues. Ref.3

Disruption phenotype: Selective loss of CD8-alpha+ classical dendritic cells (cDCs) and CD103+ dendritic cells, without abnormalities in other hematopoietic cell types or architecture. Dendritic cells are defective in cross-presentation, and mice lack virus-specific CD8+ T-cell responses to West Nile virus. Mice also show reduced priming of CD8 T-cells after pulmonary Sendai virus infection, with increased pulmonary inflammation. Mice are extremely susceptible to T.gondii infection, with decreased production of interleukin-12 (IL12) and interferon-gamma. In contrast, mice are more resistant to L.monocytogenes infection. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7

Miscellaneous: The increased protection toward L.monocytogenes infection in mice lacking Batf3 suggests that CD8-alpha+ classical dendritic cells (cDCs) and CD103+ dendritic cells are an entry point for infection by L.monocytogenes (Ref.5).

Sequence similarities: Belongs to the bZIP family.Contains 1 bZIP (basic-leucine zipper) domain.