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GTF3C2 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649700

GTF3C2 is required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in… More details

$880 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GTF3C2, Polyclonal Antibody
Full Product Name
GTF3C2 (KIAA0011, General Transcription Factor 3C Polypeptide 2, TF3C-beta, Transcription Factor IIIC 110kD Subunit, Transcription Factor IIIC Subunit beta)
Product Gene Name
anti-GTF3C2 antibody
Product Synonym Names
Anti -GTF3C2 (KIAA0011, General Transcription Factor 3C Polypeptide 2, TF3C-beta, Transcription Factor IIIC 110kD Subunit, Transcription Factor IIIC Subunit beta)
Immunogen Sequence
MDTCGVGYVA LGEAGPVGNM TVVDSPGQEV LNQLDVKTSS EMTSAEASVE MSLPTPLPGF EDSPDQRRLP PEQESLSRLE QPDLSSEMSK VSKPRASKPG RKRGGRTRKG PKRPQQPNPP SAPLVPGLLD QSNPLSTPMP KKRGRKSKAE LLLLKLSKDL DRPESQSPKR PPEDFETPSG ERPRRRAAQV ALLYLQELAE ELSTALPAPV SCPEGPKVSS PTKPKKIRQP AACPGGEEVD GAPRDEDFFL QVEAEDVEES EGPSESSSEP EPVVPRSTPR GSTSGKQKPH CRGMAPNGLP NHIMAPVWKC LHLTKDFREQ KHSYWEFAEW IPLAWKWHLL SELEAAPYLP QEEKSPLFSV QREGLPEDGT LYRINRFSSI TAHPERWDVS FFTGGPLWAL DWCPVPEGAG ASQYVALFSS PDMNETHPLS QLHSGPGLLQ LWGLGTLQQE SCPGNRAHFV YGIACDNGCI WDLKFCPSGA WELPGTPRKA PLLPRLGLLA LACSDGKVLL FSLPHPEALL AQQPPDAVKP AIYKVQCVAT LQVGSMQATD PSECGQCLSL AWMPTRPHQH LAAGYYNGMV VFWNLPTNSP LQRIRLSDGS LKLYPFQCFL AHDQAVRTLQ WCKANSHFLV SAGSDRKIKF WDLRRPYEPI NSIKRFLSTE LAWLLPYNGV TVAQDNCYAS YGLCGIHYID AGYLGFKAYF TAPRKGTVWS LSGSDWLGTI AAGDISGELI AAILPDMALN PINVKRPVER RFPIYKADLI PYQDSPEGPD HSSASSGVPN PPKARTYTET VNHHYLLFQD TDLGSFHDLL RREPMLRMQE GEGHSQLCLD RLQLEAIHKV RFSPNLDSYG WLVSGGQSGL VRIHFVRGLA SPLGHRMQLE SRAHFNAMFQ PSSPTRRPGF SPTSHRLLPT P
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human GTF3C2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
100,680 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (27548716..27580243, complement). Location: 2p23.3
OMIM
604883
3D Structure
ModBase 3D Structure for Q8WUA4
Immunogen
Full length human GTF3C2, aa1-911 (NP_001030598.1).

Product Categories/Family for anti-GTF3C2 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-GTF3C2 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-GTF3C2 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-GTF3C2 antibody

GTF3C2 polyclonal antibody. Western Blot analysis of GTF3C2 expression in Hela NE.
Mouse Anti-GTF3C2 Polyclonal Antibody – Cat# MBS649700

Western Blot (WB) of anti-GTF3C2 antibody

Western Blot analysis of GTF3C2 expression in transfected 293T cell line by GTF3C2 polyclonal antibody. Lane1: GTF3C2 transfected lysate (100.21kD). Lane2: Non-transfected lysate.
Mouse Anti-GTF3C2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS649700

Immunofluorescence (IF) of anti-GTF3C2 antibody

Immunofluorescence of purified antibody to GTF3C2 on HeLa cell. [antibody concentration 10ug/ml]
Mouse Anti-GTF3C2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS649700

Other Notes

Small volumes of anti-GTF3C2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GTF3C2 purchase

MBS649700 is an antibody targeting GTF3C2. Also known as GTF3C2 (KIAA0011, General Transcription Factor 3C Polypeptide 2, TF3C-beta, Transcription Factor IIIC 110kD Subunit, Transcription Factor IIIC Subunit beta). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GTF3C2. It may not necessarily be applicable to this product.

NCBI GI #
12652913
NCBI GeneID
2976
NCBI Accession #
AAH00212.1
UniProt Primary Accession #
Q8WUA4
UniProt Secondary Accession #
Q16632; Q9BWI7; D6W557
UniProt Related Accession #
Q8WUA4
NCBI Official Full Name
GTF3C2 protein
NCBI Official Synonym Full Names
general transcription factor IIIC, polypeptide 2, beta 110kDa
NCBI Official Symbol
GTF3C2
NCBI Official Synonym Symbols
TFIIIC110; TFIIIC-BETA
UniProt Protein Name
General transcription factor 3C polypeptide 2
UniProt Synonym Protein Names
TF3C-beta; Transcription factor IIIC 110 kDa subunit; TFIIIC 110 kDa subunit; TFIIIC110; Transcription factor IIIC subunit beta
Protein Family
General transcription factor 3C polypeptide
UniProt Gene Name
GTF3C2
UniProt Synonym Gene Names
KIAA0011; TFIIIC 110 kDa subunit; TFIIIC110
UniProt Entry Name
TF3C2_HUMAN
NCBI Protein Information
general transcription factor 3C polypeptide 2; TF3C-beta; TFIIIC 110 kDa subunit; transcription factor IIIC subunit beta; transcription factor IIIC 110 kDa subunit

UniProt Comments for GTF3C2

Function: Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

Subunit structure: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Ref.1

Subcellular location: Nucleus.

Sequence similarities: Contains 4 WD repeats.
Show more

Research Articles on GTF3C2

1. Evidence against the model that pol III transcription can be effectively modulated through the specific induction of TFIIIC110.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GTF3C2 antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 RNA Polymerase III Abortive And Retractive Initiation Pathway antibodies  RNA Polymerase III Abortive And Retractive Initiation Pathway Diagram
 RNA Polymerase III Transcription Pathway antibodies  RNA Polymerase III Transcription Pathway Diagram
 RNA Polymerase III Transcription Initiation Pathway antibodies  RNA Polymerase III Transcription Initiation Pathway Diagram
 RNA Polymerase III Transcription Initiation From Type 1 Promoter Pathway antibodies  RNA Polymerase III Transcription Initiation From Type 1 Promoter Pathway Diagram
 RNA Polymerase III Transcription Initiation From Type 2 Promoter Pathway antibodies  RNA Polymerase III Transcription Initiation From Type 2 Promoter Pathway Diagram
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