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LRRC4C Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649720

NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM]. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LRRC4C, Monoclonal Antibody
Full Product Name
LRRC4C (KIAA1580, NGL1, Leucine-rich Repeat-containing Protein 4C, Netrin-G1 Ligand))
Product Gene Name
anti-LRRC4C antibody
Product Synonym Names
Anti -LRRC4C (KIAA1580, NGL1, Leucine-rich Repeat-containing Protein 4C, Netrin-G1 Ligand))
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
1G5
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human LRRC4C.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
71,950 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (40135524..41481186, complement). Location: 11p12
OMIM
608817
3D Structure
ModBase 3D Structure for Q9HCJ2
Immunogen
Partial recombinant corresponding to aa541-641 from human LRRC4C (NP_065980) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-LRRC4C antibody

Antibodies; Abs to Netrin
Applications Tested/Suitable for anti-LRRC4C antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-LRRC4C antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-LRRC4C antibody

Western Blot detection against Immunogen (37.11kD).
Mouse Anti-LRRC4C Monoclonal Antibody – Cat# MBS649720

Western Blot (WB) of anti-LRRC4C antibody

Western Blot analysis of LRRC4C expression in transfected 293T cell line by LRRC4C monoclonal antibody.|Lane 1: LRRC4C transfected lysate (71.9kD).|Lane 2: Non-transfected lysate.
Mouse Anti-LRRC4C Monoclonal Antibody, Western Blot (WB) – Cat# MBS649720

Testing Data of anti-LRRC4C antibody

Detection limit for recombinant GST tagged LRRC4C is 0.1ng/ml as a capture antibody.
Mouse Anti-LRRC4C Monoclonal Antibody, Testing Data – Cat# MBS649720

Other Notes

Small volumes of anti-LRRC4C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LRRC4C purchase

MBS649720 is an antibody targeting LRRC4C. Also known as LRRC4C (KIAA1580, NGL1, Leucine-rich Repeat-containing Protein 4C, Netrin-G1 Ligand)). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for LRRC4C. It may not necessarily be applicable to this product.

NCBI GI #
73909151
NCBI GeneID
57689
NCBI Accession #
AAH41374.3
UniProt Primary Accession #
Q9HCJ2
UniProt Secondary Accession #
Q7L0N3; A8K0T1
UniProt Related Accession #
Q9HCJ2
NCBI Official Full Name
LRRC4C protein
NCBI Official Synonym Full Names
leucine rich repeat containing 4C
NCBI Official Symbol
LRRC4C
NCBI Official Synonym Symbols
NGL1; NGL-1
UniProt Protein Name
Leucine-rich repeat-containing protein 4C
UniProt Synonym Protein Names
Netrin-G1 ligand
Protein Family
Leucine-rich repeat-containing protein
UniProt Gene Name
LRRC4C
UniProt Synonym Gene Names
KIAA1580; NGL1; NGL-1
UniProt Entry Name
LRC4C_HUMAN
NCBI Protein Information
leucine-rich repeat-containing protein 4C; netrin-G1 ligand

NCBI Summary for LRRC4C

NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]

UniProt Comments for LRRC4C

Function: May promote neurite outgrowth of developing thalamic neurons. Ref.6

Subunit structure: Interacts with NTNG1 and WHRN. Ref.6

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Single-pass type I membrane protein Ref.6 Ref.7.

Tissue specificity: Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show very weak or no expression. Ref.6

Domain: The LRR region is both necessary and sufficient for the interaction with NTNG1.

Sequence similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 9 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain.
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Research Articles on LRRC4C

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LRRC4C antibody

 Reference Product  PubMed Publications
 NTNG1 antibody  >3 publications with LRRC4C and NTNG1
 NTNG2 antibody  >2 publications with LRRC4C and NTNG2

Pathways associated with anti-LRRC4C antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with anti-LRRC4C antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with LRRC4C and Neoplasms
 Nervous System Diseases Antibodies  >1 publications with LRRC4C and Nervous System Diseases

Organs/Tissues associated with anti-LRRC4C antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with LRRC4C and Brain
 Uncharacterized Tissue Antibodies  >1 publications with LRRC4C and Uncharacterized Tissue
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