RGS20 Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins

By similarity. Ref.7

Subunit structure: Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1

By similarity.

Subcellular location: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm/cell membrane and the nucleus

By similarity. Anchored to the membrane through palmitoylation

By similarity.

Tissue specificity: Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.

Post-translational modification: Fatty acylated. Heavily palmitoylated in the cysteine string motif

By similarity.N- and O-glycosylated in synapsomal membranes

By similarity.Serine phosphorylated in synapsomal membranes

By similarity.Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits

By similarity.

Sequence similarities: Contains 1 RGS domain.