ENOX2 Antibody – Rabbit Polyclonal

This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Function: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Ref.10 Ref.15

Cofactor: Copper. Ref.1

Enzyme regulation: Inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids. Ref.1 Ref.9 Ref.10

Subcellular location: Cell membrane. Secreted › extracellular space. Note: Extracellular and plasma membrane-associated. Ref.8 Ref.10 Ref.13

Tissue specificity: Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.

Post-translational modification: Glycosylated. Ref.8

Miscellaneous: Has several properties associated with prions including resistance to proteases, resistance to cyanogen bromide digestion, and the ability to form amyloid filaments resembling those of spongiform encephalopathies.

Sequence similarities: Belongs to the ENOX family.Contains 1 RRM (RNA recognition motif) domain.

Sequence caution: The sequence AAB30428.1 differs from that shown. Reason: Frameshift at positions 302 and 357.