CYTH1 Antibody – Mouse Monoclonal

Function: Promotes guanine-nucleotide exchange on ARF6. Promotes the activation of ARF6 through replacement of GDP with GTP.

Subunit structure: Interacts with TRIM23 and CYTIP

By similarity.

Subcellular location: Cell membrane

By similarity.

Tissue specificity: Present in all tissues tested, with highest protein levels in brain and adrenal.

Developmental stage: On embryonic days 15 (E15) and E18, expression is seen in the mantle and ventricular germinal zones throughout the neuraxis. On postnatal days 0 (P0) and P7, expression is seen in the cerebral neocortex, olfactory mitral and granule cell layers, hippocampal pyramidal and dentate granule cells and the striatum. A lower expression is seen in gray matter in di-, mes- and met-encephali. In the cerebellum, the expression is evident in the external and internal granule cell layers and Purkinje cell layer. On P14, a decreased expression is seen in the di-, mes- and met-encephali. On P21 and thereafter, expression is seen in the olfactory mitral and granule cells, dentate granule cells and the cerebellar granule cells and Purkinje cells. Ref.3

Sequence similarities: Contains 1 PH domain.Contains 1 SEC7 domain.