GPER1: Receptor for estrogen. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: Golgi apparatus; basolateral plasma membrane; dendrite; early endosome; integral to membrane; nuclear envelope; trans-Golgi network; cytosol; postsynaptic membrane; recycling endosome; perinuclear region of cytoplasm; keratin filament; cytoplasm; intracellular; dendritic shaft; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; endoplasmic reticulum; postsynaptic density; Golgi membrane; presynaptic membrane; axon; mitochondrial membrane; plasma membrane; presynaptic active zone; nerve terminal; cell junction; nucleus
Molecular Function: G-protein coupled receptor activity; estrogen receptor activity; hormone binding; steroid hormone receptor activity; drug binding; mineralocorticoid receptor activity; chromatin binding; steroid binding
Biological Process: positive regulation of apoptosis; generation of action potential; positive regulation of caspase activity; nuclear fragmentation during apoptosis; positive regulation of vasodilation; negative regulation of DNA metabolic process; positive regulation of neurotransmitter secretion; negative regulation of leukocyte activation; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; positive regulation of MAPKKK cascade; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; inflammatory response; steroid hormone receptor signaling pathway; positive regulation of neurogenesis; cytosolic calcium ion homeostasis; negative regulation of lipid biosynthetic process; positive regulation of insulin secretion; positive regulation of inositol trisphosphate biosynthetic process; apoptotic chromosome condensation; negative regulation of fat cell differentiation; positive regulation of phosphoinositide 3-kinase cascade; mineralocorticoid receptor signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; negative regulation of inflammatory response; innate immune response; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cell migration
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