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SEPT8 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649814

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis. May play a role in platelet secretion. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SEPT8, Monoclonal Antibody
Full Product Name
SEPT8 (Septin 8, Septin-8, KIAA0202)
Product Gene Name
anti-SEPT8 antibody
Product Synonym Names
Anti -SEPT8 (Septin 8, Septin-8, KIAA0202)
Immunogen Sequence
MKKLDSKVNI IPIIAKADTI SKSELHKFKI KIMGELVSNG VQIYQFPTDD EAVAEINAVM NAHLPFAVVG STEEVKVGNK LVRARQYPWG VVQVENENHC DFVKLREMLI RVNMEDLREQ THSRHYELYR RCKLEEMGFQ DSDGDSQPFS LQETYEAKRK EFLSELQRKE EEMRQMFVNK VKETELELKE KERELHEKFE HLKRVHQEEK RKVEEKRREL EEETNAFNRR KAAVEALQSQ ALHATSQQPL RKDKD
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
1G3-7D1
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SEPT8.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
55,756 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (132086509..132113976, complement). Location: 5q31
OMIM
608418
3D Structure
ModBase 3D Structure for Q92599
Immunogen
Full-length recombinant corresponding to aa1-259 from SEPT8 (AAH01329) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-SEPT8 antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-SEPT8 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SEPT8 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml

Western Blot (WB) of anti-SEPT8 antibody

Western Blot detection against Immunogen (54.49kD)
Mouse Anti-SEPT8 Monoclonal Antibody – Cat# MBS649814

Immunohistochemistry (IHC) of anti-SEPT8 antibody

Immunoperoxidase of monoclonal antibody to SEPT8 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3ug/ml]
Mouse Anti-SEPT8 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS649814

Other Notes

Small volumes of anti-SEPT8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEPT8 purchase

MBS649814 is an antibody targeting SEPT8. Also known as SEPT8 (Septin 8, Septin-8, KIAA0202). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SEPT8. It may not necessarily be applicable to this product.

NCBI GI #
223461469
NCBI GeneID
23176
NCBI Accession #
AAI40760.1
UniProt Primary Accession #
Q92599
UniProt Secondary Accession #
Q8IX36; Q8IX37; Q9BVB3; A6NC65; A6NKP6
UniProt Related Accession #
Q92599
NCBI Official Full Name
SEPT8 protein
NCBI Official Synonym Full Names
septin 8
NCBI Official Symbol
SEPT8
NCBI Official Synonym Symbols
SEP2
UniProt Protein Name
Septin-8
UniProt Gene Name
SEPT8
UniProt Synonym Gene Names
KIAA0202
UniProt Entry Name
SEPT8_HUMAN
NCBI Protein Information
septin-8

NCBI Summary for SEPT8

This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. [provided by RefSeq, Jun 2012]
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UniProt Comments for SEPT8

Function: Filament-forming cytoskeletal GTPase

By similarity. May play a role in cytokinesis

Potential. May play a role in platelet secretion. Ref.10

Subunit structure: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation

By similarity. Interacts with CDK14, SEPT4, SEPT5 and SEPT7

By similarity. Ref.1 Ref.2 Ref.9 Ref.10

Subcellular location: Cytoplasm

By similarity. Cytoplasm › cytoskeleton

By similarity. Note: In platelets, found in areas surrounding alpha-granules. Ref.10

Tissue specificity: Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. Ref.1 Ref.2 Ref.10 Ref.11

Sequence similarities: Belongs to the septin family.

Sequence caution: The sequence AAG09407.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH01329.1 differs from that shown. Reason: Erroneous initiation. The sequence AAO13878.1 differs from that shown. Reason: Erroneous initiation. The sequence AAO13879.1 differs from that shown. Reason: Erroneous initiation. The sequence AAO13880.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA13193.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on SEPT8

1. Cloning, overexpression, purification and preliminary characterization of human septin 8. Fluorescence emission spectra, analytic gel filtration and DLS reflect the sample oligomeric heterogeneity with the predominance of dimers in solution.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SEPT8 antibody

 Reference Product  PubMed Publications
 SEPT5 antibody  >9 publications with SEPT8 and SEPT5
 SEPT4 antibody  >7 publications with SEPT8 and SEPT4
 SEPT2 antibody  >5 publications with SEPT8 and SEPT2

Pathways associated with anti-SEPT8 antibody

 Products by Pathway  Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram

Diseases associated with anti-SEPT8 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with SEPT8 and Brain Diseases
 Neurodegenerative Diseases Antibodies  >2 publications with SEPT8 and Neurodegenerative Diseases
 Nervous System Diseases Antibodies  >2 publications with SEPT8 and Nervous System Diseases
 Atrophy Antibodies  >1 publications with SEPT8 and Atrophy
 Poisoning Antibodies  >1 publications with SEPT8 and Poisoning
 Movement Disorders Antibodies  >1 publications with SEPT8 and Movement Disorders

Organs/Tissues associated with anti-SEPT8 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with SEPT8 and Brain
 Nerve Antibodies  >3 publications with SEPT8 and Nerve
 Eye Antibodies  >3 publications with SEPT8 and Eye
 Muscle Antibodies  >2 publications with SEPT8 and Muscle
 Heart Antibodies  >2 publications with SEPT8 and Heart
 Blood Antibodies  >1 publications with SEPT8 and Blood
 Skin Antibodies  >1 publications with SEPT8 and Skin
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