Src-Like Adaptor (SLA) Antibody – Rabbit Polyclonal

Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Ref.4 Ref.7

Subunit structure: Interacts with EPHA2, VAV1, LCP2 and PDGFRB

By similarity. Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain. Ref.7

Subcellular location: Cytoplasm

By similarity. Endosome

By similarity. Note: Colocalizes with endosomes

By similarity.

Tissue specificity: Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas. Ref.3

Induction: By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins. Ref.2

Domain: The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.

Sequence similarities: Contains 1 SH2 domain.Contains 1 SH3 domain.