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Serine Racemase (SRR) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649861

MBS649861 is an antibody targeting SRR. Also known as Serine Racemase (SRR, D-serine Ammonia-lyase, D-serine Dehydratase, L-serine Ammonia-lyase, L-serine Dehydratase, ILV1, ISO1). Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Serine Racemase (SRR), Polyclonal Antibody
Full Product Name
Serine Racemase (SRR, D-serine Ammonia-lyase, D-serine Dehydratase, L-serine Ammonia-lyase, L-serine Dehydratase, ILV1, ISO1)
Product Gene Name
anti-SRR antibody
Product Synonym Names
Anti -Serine Racemase (SRR, D-serine Ammonia-lyase, D-serine Dehydratase, L-serine Ammonia-lyase, L-serine Dehydratase, ILV1, ISO1)
Immunogen Sequence
MCAQYCISFA DVEKAHINIR DSIHLTPVLT SSILNQLTGR NLFFKCELFQ KTGSFKIRGA LNAVRSLVPD ALERKPKAVV THSSGNHGQA LTYAAKLEGI PAYIVVPQTA PDCKKLAIQA YGASIVYCEP SDESRENVAK RVTEETEGIM VHPNQEPAVI AGQGTIALEV LNQVPLVDAL VVPVGGGGML AGIAITVKAL KPSVKVYAAE PSNADDCYQS KLKGKLMPNL YPPETIADGV KSSIGLNTWP IIRDLVDDIF TVTEDEIKCA TQLVWERMKL LIEPTAGVGV AAVLSQHFQT VSPEVKNICI VLSGGNVDLT SSITWVKQAE RPASYQSVSV
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid.
Purity/Purification
Serum
Serum
Specificity
Recognizes human SRR.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
36,566 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (2207244..2228553). Location: 17p13
OMIM
606477
3D Structure
ModBase 3D Structure for Q9GZT4
Immunogen
Full length human SRR, aa1-340 (NP_068766.1).

Product Categories/Family for anti-SRR antibody

Antibodies; Abs to Enzymes; Racemase
Applications Tested/Suitable for anti-SRR antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-SRR antibody
Suitable for use in Western Blot and Immunoprecipitation.

Western Blot (WB) of anti-SRR antibody

Western Blot analysis of SRR expression in transfected 293T cell line by SRR polyclonal antibody. Lane 1: SRR transfected lysate (36.6kD). Lane 2: Non-transfected lysate.
Rabbit Anti-SRR Polyclonal Antibody – Cat# MBS649861

Immunoprecipitation (IP) of anti-SRR antibody

Immunoprecipitation of SRR transfected lysate using SRR rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with SRR mouse polyclonal antibody.
Rabbit Anti-SRR Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS649861

Other Notes

Small volumes of anti-SRR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SRR. It may not necessarily be applicable to this product.

NCBI GI #
11345492
NCBI GeneID
63826
NCBI Accession #
NP_068766.1
UniProt Primary Accession #
Q9GZT4
UniProt Secondary Accession #
Q6IA55; D3DTI5
UniProt Related Accession #
Q9GZT4
GenBank Nucleotide #
NM_021947.1
NCBI Official Full Name
serine racemase
NCBI Official Synonym Full Names
serine racemase
NCBI Official Symbol
SRR
NCBI Official Synonym Symbols
ILV1; ISO1
UniProt Protein Name
Serine racemase
UniProt Synonym Protein Names
D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase
Protein Family
Probable serine racemase
UniProt Gene Name
SRR
UniProt Entry Name
SRR_HUMAN
NCBI Protein Information
serine racemase; D-serine dehydratase; L-serine dehydratase; D-serine ammonia-lyase; L-serine ammonia-lyase

UniProt Comments for SRR

Function: Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. Ref.1 Ref.8

Catalytic activity: L-serine = D-serine. Ref.8L-serine = pyruvate + NH3. Ref.8D-serine = pyruvate + NH3. Ref.8

Cofactor: Pyridoxal phosphate. Ref.8

Enzyme regulation: Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.

Subunit structure: Homodimer. Ref.8

Tissue specificity: Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver. Ref.2

Post-translational modification: S-nitrosylated, leading to decrease the enzyme activity

By similarity.

Sequence similarities: Belongs to the serine/threonine dehydratase family.

Biophysicochemical propertiesKinetic parameters:KM=6.5 mM for L-serine Ref.8
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Research Articles on SRR

1. S84A serine racemase mutant behaved like serine dehydratase, whereas A65S serine dehydratase mutant acquired an additional function of using D-serine as a substrate.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SRR antibody

 Reference Product  PubMed Publications
 SHMT1 antibody  >3 publications with SRR and SHMT1
 SDS antibody  >1 publications with SRR and SDS

Pathways associated with anti-SRR antibody

 Products by Pathway  Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram

Diseases associated with anti-SRR antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >30 publications with SRR and Cardiovascular Diseases
 Brain Diseases Antibodies  >15 publications with SRR and Brain Diseases
 Liver Diseases Antibodies  >13 publications with SRR and Liver Diseases
 Hepatitis Antibodies  >12 publications with SRR and Hepatitis
 Liver Neoplasms Antibodies  >12 publications with SRR and Liver Neoplasms
 Hypertension Antibodies  >11 publications with SRR and Hypertension
 Genital Diseases, Male Antibodies  >9 publications with SRR and Genital Diseases, Male
 Disease Models, Animal Antibodies  >8 publications with SRR and Disease Models, Animal
 Liver Cirrhosis Antibodies  >5 publications with SRR and Liver Cirrhosis
 Kidney Diseases Antibodies  >5 publications with SRR and Kidney Diseases

Organs/Tissues associated with anti-SRR antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >71 publications with SRR and Blood
 Brain Antibodies  >43 publications with SRR and Brain
 Liver Antibodies  >40 publications with SRR and Liver
 Heart Antibodies  >34 publications with SRR and Heart
 Lung Antibodies  >31 publications with SRR and Lung
 Kidney Antibodies  >25 publications with SRR and Kidney
 Bone Antibodies  >25 publications with SRR and Bone
 Muscle Antibodies  >13 publications with SRR and Muscle
 Stomach Antibodies  >11 publications with SRR and Stomach
 Vascular Antibodies  >9 publications with SRR and Vascular
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