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PLAA Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649979

PLAA stimulates human neutrophil aggregation and release of lysosomal enzymes, superoxide, and eicosanoids. It plays an important role in the regulation of specific inflammatory processes connected to such diseases as inflammatory bowel disease, pancreatitis,… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PLAA, Monoclonal Antibody
Full Product Name
PLAA (Phospholipase A-2-activating Protein, PLA2P, PLAP, FLJ11281, FLJ12699)
Product Gene Name
anti-PLAA antibody
Product Synonym Names
Anti -PLAA (Phospholipase A-2-activating Protein, PLA2P, PLAP, FLJ11281, FLJ12699)
Immunogen Sequence
KNIHIALATL ALNYSVCFHK DHNIEGKAQC LSLISTILEV VQDLEATFRL LVALGTLISD DSNAVQLAKS LGVDSQIKKY SSVSEPAKVS ECCRFILNLL
Clonality
Monoclonal
Isotype
IgG2b Lambda
Clone Number
2C1
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human PLAA.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
87,157 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (26903368..26947468, complement). Location: 9p21
OMIM
603873
3D Structure
ModBase 3D Structure for Q9Y263
Immunogen
Partial recombinant corresponding to aa639-738 from PLaa (NP_004244) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-PLAA antibody

Antibodies; Abs to Enzymes; Phospholipase
Applications Tested/Suitable for anti-PLAA antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PLAA antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-PLAA antibody

Western Blot detection against Immunogen (36.74kD).
Mouse Anti-PLAA Monoclonal Antibody – Cat# MBS649979

Testing Data of anti-PLAA antibody

Detection limit for recombinant GST tagged PLAA is ~3ng/ml as a capture antibody.
Mouse Anti-PLAA Monoclonal Antibody, Testing Data – Cat# MBS649979

Other Notes

Small volumes of anti-PLAA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLAA purchase

MBS649979 is an antibody targeting PLAA. Also known as PLAA (Phospholipase A-2-activating Protein, PLA2P, PLAP, FLJ11281, FLJ12699). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PLAA. It may not necessarily be applicable to this product.

NCBI GI #
72534670
NCBI GeneID
9373
NCBI Accession #
NP_001026859.1
UniProt Primary Accession #
Q9Y263
UniProt Secondary Accession #
Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y5L1
UniProt Related Accession #
Q9Y263
GenBank Nucleotide #
NM_001031689.2
NCBI Official Full Name
phospholipase A-2-activating protein
NCBI Official Synonym Full Names
phospholipase A2-activating protein
NCBI Official Symbol
PLAA
NCBI Official Synonym Symbols
DOA1; PLAP; PLA2P
UniProt Protein Name
Phospholipase A-2-activating protein
Protein Family
Phospholipase A-2-activating protein
UniProt Gene Name
PLAA
UniProt Synonym Gene Names
PLAP; PLA2P; PLAP
UniProt Entry Name
PLAP_HUMAN
NCBI Protein Information
phospholipase A-2-activating protein; DOA1 homolog; phospholipase A2 activating protein

UniProt Comments for PLAA

Function: Involved in the maintenance of ubiquitin levels

By similarity.

Subunit structure: Interacts with ubiquitin. Interacts with VCP. Ref.11

Domain: The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus. Ref.12The PFU domain mediates interaction with ubiquitin. Ref.12

Sequence similarities: Belongs to the WD repeat PLAP family.Contains 6 ARM repeats.Contains 1 PFU domain.Contains 1 PUL domain.Contains 7 WD repeats.

Sequence caution: The sequence AAD03030.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAD42075.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAD42075.1 differs from that shown. Reason: Frameshift at position 698. The sequence BAA92105.1 differs from that shown. Reason: Erroneous termination at position 545. Translated as Gln.The sequence BAD97264.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAB42881.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAH72641.1 differs from that shown. Reason: Erroneous gene model prediction.
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Research Articles on PLAA

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLAA antibody

 Reference Product  PubMed Publications
 PDIA3 antibody  >4 publications with PLAA and PDIA3
 VCP antibody  >2 publications with PLAA and VCP
 CAV1 antibody  >1 publications with PLAA and CAV1

Pathways associated with anti-PLAA antibody

 Products by Pathway  Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-PLAA antibody

 Disease Name  Pubmed Publications
 Poisoning Antibodies  >62 publications with PLAA and Poisoning
 Drug-Induced Liver Injury Antibodies  >48 publications with PLAA and Drug-Induced Liver Injury
 Liver Diseases Antibodies  >47 publications with PLAA and Liver Diseases
 Nervous System Diseases Antibodies  >17 publications with PLAA and Nervous System Diseases
 Necrosis Antibodies  >13 publications with PLAA and Necrosis
 Neurotoxicity Syndromes Antibodies  >10 publications with PLAA and Neurotoxicity Syndromes
 Disease Models, Animal Antibodies  >8 publications with PLAA and Disease Models, Animal
 Kidney Diseases Antibodies  >8 publications with PLAA and Kidney Diseases
 Lung Diseases Antibodies  >5 publications with PLAA and Lung Diseases
 Inflammation Antibodies  >5 publications with PLAA and Inflammation

Organs/Tissues associated with anti-PLAA antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >145 publications with PLAA and Liver
 Blood Antibodies  >93 publications with PLAA and Blood
 Kidney Antibodies  >20 publications with PLAA and Kidney
 Lung Antibodies  >12 publications with PLAA and Lung
 Brain Antibodies  >12 publications with PLAA and Brain
 Vascular Antibodies  >8 publications with PLAA and Vascular
 Muscle Antibodies  >4 publications with PLAA and Muscle
 Adipose Tissue Antibodies  >4 publications with PLAA and Adipose Tissue
 Bone Antibodies  >4 publications with PLAA and Bone
 Connective Tissue Antibodies  >4 publications with PLAA and Connective Tissue
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