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Spinophilin (PPP1R9B) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6500501

Spinophilin/Neurabin-II has been found to be enriched at the postsynaptic density fraction in the brain and in the adherens junction fraction in rat liver. Within the brain, Spinophilin/Neurabin-II is localized in the heads of dendritic spines.… More details

$1290 / 0.1 mL +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Spinophilin (Ppp1r9b), Polyclonal Antibody
Full Product Name
Spinophilin (Neurabin-II) (PE)
Product Gene Name
anti-Ppp1r9b antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes rat spinophilin at ~120kD. Also recognizes a band at ~95kD which is suspected to be a cleavage product of spinophilin.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
89,646 Da
3D Structure
ModBase 3D Structure for O35274
Immunogen
GST fusion protein corresponding to residues 286-390 of rat brain Spinophilin
Conjugate
PE
Note
Preservative Free

Product Categories/Family for anti-Ppp1r9b antibody

Antibodies; Neuroscience
Applications Tested/Suitable for anti-Ppp1r9b antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-Ppp1r9b antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-Ppp1r9b antibody

Western Blot analysis of rat brain microsomal preparation using MBS617805 0.5ug/ml.
Rabbit Anti-PPP1R9B Polyclonal Antibody – Cat# MBS6500501

Product References and Citations for anti-Ppp1r9b antibody

1. Ide, N., et al., Biochem. Biophys. Res. Commun. 244: 258-262 (1998). 2. Satoh, A., et al., J. Biol. Chem. 273: 3470-3475 (1998). 3. Allen, P.B., et al., Proc. Natl. Acad. Sci. USA 94: 9956-9961 (1997). 4. Marx, S.O., et al., J. Cell Biol. 153: 699-708 (2001). 5. Terry-Lorenzo, R.T., et al., J. Biol. Chem. 277: 46, 535-46, 543 (2002).

Other Notes

Small volumes of anti-Ppp1r9b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ppp1r9b purchase

MBS6500501 is an antibody targeting Ppp1r9b. Also known as Spinophilin (Neurabin-II) (PE). Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Ppp1r9b. It may not necessarily be applicable to this product.

NCBI GI #
16758226
NCBI GeneID
84686
NCBI Accession #
NP_445926.1
UniProt Primary Accession #
O35274
UniProt Related Accession #
O35274
GenBank Nucleotide #
NM_053474.1
NCBI Official Full Name
neurabin-2
NCBI Official Synonym Full Names
protein phosphatase 1, regulatory subunit 9B
NCBI Official Symbol
Ppp1r9b
NCBI Official Synonym Symbols
Neb2
UniProt Protein Name
Neurabin-2
UniProt Synonym Protein Names
Neurabin-II; Neural tissue-specific F-actin-binding protein II; PP1bp134; Protein phosphatase 1 regulatory subunit 9B; Spinophilin; p130
Protein Family
Neurabin
UniProt Gene Name
Ppp1r9b
UniProt Entry Name
NEB2_RAT
NCBI Protein Information
neurabin-2; p130; PP1bp134; neurabin 2; nuerabin 2; neurabin-II; spinophilin; neural tissue-specific F-actin-binding protein II

NCBI Summary for Ppp1r9b

interacts with protein phosphatase 1 and actin filaments; involved in regulation of synaptic transmission [RGD, Feb 2006]

UniProt Comments for Ppp1r9b

Spinophilin: actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain.

Protein type: Protein phosphatase, regulatory subunit; Adaptor/scaffold

Cellular Component: nucleoplasm; cortical actin cytoskeleton; adherens junction; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; intracellular; filopodium

Molecular Function: protein binding; actin binding; protein phosphatase 1 binding

Biological Process: regulation of synaptic transmission; cell migration; regulation of protein amino acid phosphorylation; filopodium formation; dendrite development; calcium-mediated signaling; actin filament organization; negative regulation of cell growth; regulation of cell proliferation
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Research Articles on Ppp1r9b

1. Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Ppp1r9b antibody

 Reference Product  PubMed Publications
 Ppp1ca antibody  >1 publications with Ppp1r9b and Ppp1ca

Diseases associated with anti-Ppp1r9b antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >2 publications with Ppp1r9b and Mental Disorders
 Neurobehavioral Manifestations Antibodies  >2 publications with Ppp1r9b and Neurobehavioral Manifestations
 Cognition Disorders Antibodies  >2 publications with Ppp1r9b and Cognition Disorders
 Schizophrenia Antibodies  >1 publications with Ppp1r9b and Schizophrenia
 Bipolar Disorder Antibodies  >1 publications with Ppp1r9b and Bipolar Disorder
 Cell Transformation, Neoplastic Antibodies  >1 publications with Ppp1r9b and Cell Transformation, Neoplastic
 Mammary Neoplasms, Animal Antibodies  >1 publications with Ppp1r9b and Mammary Neoplasms, Animal
 Musculoskeletal Abnormalities Antibodies  >1 publications with Ppp1r9b and Musculoskeletal Abnormalities
 Sinusitis Antibodies  >1 publications with Ppp1r9b and Sinusitis

Organs/Tissues associated with anti-Ppp1r9b antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with Ppp1r9b and Brain
 Eye Antibodies  >1 publications with Ppp1r9b and Eye
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