Macrophage Derived Chemokine (CCL22) Active Protein

Name: CCL22 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS650196
Price: 705 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650196

MBS650196 is an active protein targeting CCL22. Also known as Macrophage Derived Chemokine, Recombinant, Human (MDC). More details

$705 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Macrophage Derived Chemokine (CCL22), Active Protein

Full Product Name

Macrophage Derived Chemokine, Recombinant, Human (MDC)

Product Gene Name

CCL22 active protein

Form/Format

Supplied as a lyophilized powder. No preservative added. Reconstitute with sterile dH2O to 0.1-1mg/ml.

Purity/Purification

Highly Purified
~98% (SDS-PAGE, HPLC)

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

8.0kD, 67 amino acid residues

Chromosome Location

Chromosome: 16; NC_000016.9 (57392695..57400102). Location: 16q13

OMIM

602957

3D Structure

ModBase 3D Structure for O00626

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

The biological activity of recombinant human MDC is determined by measuring the dose-dependent stimulation of chemotaxis with human T-cells. Significant stimulation of chemotaxis is observed with 10-100 ng/ml. MDC is a C-C chemokine.

Endotoxin Level

~0.1ng/ug

Product Categories/Family for CCL22 active protein

Growth Factors; Cytokines; Growth Factors-MDC

Other Notes

Small volumes of CCL22 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL22. It may not necessarily be applicable to this product.

NCBI GI #

1931581

NCBI GeneID

6367

UniProt Primary Accession #

O00626

UniProt Secondary Accession #

A0N0Q6; B2R4W2

UniProt Related Accession #

O00626

NCBI Official Full Name

macrophage-derived chemokine

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 22

NCBI Official Symbol

CCL22

NCBI Official Synonym Symbols

MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; MGC34554; A-152E5.1

UniProt Protein Name

C-C motif chemokine 22

UniProt Synonym Protein Names

CC chemokine STCP-1; MDC(1-69); Macrophage-derived chemokine; Small-inducible cytokine A22; Stimulated T-cell chemotactic protein 1

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL22

UniProt Synonym Gene Names

MDC; SCYA22

UniProt Entry Name

CCL22_HUMAN

NCBI Protein Information

C-C motif chemokine 22; MDC(1-69); OTTHUMP00000164658; CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22

NCBI Summary for CCL22

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq]

UniProt Comments for CCL22

Function: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

Subcellular location: Secreted.

Tissue specificity: Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. Ref.10

Post-translational modification: The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Research Articles on CCL22

1. Contact between monocyte-derived dendritic cells and HCV-JFH1-infected Huh7 cells induced the expression of CCL17 and CCL22.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL22 active protein

Reference Product	PubMed Publications
CCR4 active protein	>172 publications with CCL22 and CCR4
CCL19 active protein	>33 publications with CCL22 and CCL19

Pathways associated with CCL22 active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with CCL22 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>120 publications with CCL22 and Inflammation
Skin Diseases Antibodies	>82 publications with CCL22 and Skin Diseases
Neoplasms Antibodies	>79 publications with CCL22 and Neoplasms
Lung Diseases Antibodies	>79 publications with CCL22 and Lung Diseases
Asthma Antibodies	>63 publications with CCL22 and Asthma
Dermatitis, Atopic Antibodies	>51 publications with CCL22 and Dermatitis, Atopic
Respiratory Hypersensitivity Antibodies	>48 publications with CCL22 and Respiratory Hypersensitivity
Nervous System Diseases Antibodies	>29 publications with CCL22 and Nervous System Diseases
Carcinoma Antibodies	>21 publications with CCL22 and Carcinoma
Leukemia Antibodies	>21 publications with CCL22 and Leukemia

Organs/Tissues associated with CCL22 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>361 publications with CCL22 and Blood
Thymus Antibodies	>113 publications with CCL22 and Thymus
Skin Antibodies	>88 publications with CCL22 and Skin
Lung Antibodies	>74 publications with CCL22 and Lung
Bone Antibodies	>29 publications with CCL22 and Bone
Kidney Antibodies	>10 publications with CCL22 and Kidney
Eye Antibodies	>8 publications with CCL22 and Eye
Pharynx Antibodies	>3 publications with CCL22 and Pharynx
Mouth Antibodies	>2 publications with CCL22 and Mouth