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Interleukin 19 (IL19) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650225

IL-19 is a single, non-glycosylated polypeptide with 152 amino acids. It plays an important role in regulating development and functioning of the skin. More details

$1005 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin 19 (IL19), Active Protein
Full Product Name
Interleukin 19, Recombinant, Mouse (Interleukin-19, IL-19, IL19
Product Gene Name
Form/Format
Suppied as a lyophilized powder with no additives. Reconstitute with streile ddH2O to a concentration of 0.1-0.5mg/ml.
Purity/Purification
Highly Purified
~95% (SDS-PAGE and HPLC). Endotoxin: 0.1ng/ug.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
Molecular Weight
17.7kD
Chromosome Location
Chromosome: 1; NC_000001.10 (206972215..207016325). Location: 1q32.2
3D Structure
ModBase 3D Structure for Q5VUT3
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Mouse IL-19 is fully biologically active when compared to standard. Significant STAT3 activation is observed with > 100ng/ml of recombinant mouse IL-19.

Other Notes

Small volumes of IL19 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL19 purchase

MBS650225 is an active protein targeting IL19. Also known as Interleukin 19, Recombinant, Mouse (Interleukin-19, IL-19, IL19.

Additional Details

NCBI/Uniprot data below describe general gene information for IL19. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
interleukin 19
NCBI Official Synonym Full Names
interleukin 19
NCBI Official Symbol
IL19
NCBI Official Synonym Symbols
MDA1; NG.1; ZMDA1; IL-10C
UniProt Protein Name
Interleukin 19
Protein Family
UniProt Gene Name
IL19
UniProt Entry Name
Q5VUT3_HUMAN
NCBI Protein Information
interleukin-19; OTTHUMP00000034568; OTTHUMP00000216804; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein

NCBI Summary for IL19

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq]
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UniProt Comments for IL19

IL19: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family.

Protein type: Secreted, signal peptide; Apoptosis; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: extracellular space; extracellular region

Molecular Function: cytokine activity

Biological Process: apoptosis; positive regulation of JAK-STAT cascade; immune response; inflammatory response; signal transduction; interleukin-6 biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL19 active protein

 Reference Product  PubMed Publications
 IL20RA active protein  >2 publications with IL19 and IL20RA

Organs/Tissues associated with IL19 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with IL19 and Lung
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