Fibroblast Growth Factor 17 (FGF17) Active Protein

Name: FGF17 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS650236
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650236

The FGFs play key roles in controlling tissue growth, morphogenesis and repair in animals. FGF-17 is a newly discovered heparin binding growth factor that stimulates the proliferation and activation of cells that express FGF receptors. Recombinant Human… More details

$370 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Fibroblast Growth Factor 17 (FGF17), Active Protein

Full Product Name

Fibroblast Growth Factor 17, Recombinant, Human (FGF17)

Product Gene Name

FGF17 active protein

Host

E Coli

Form/Format

The sterile ltered solution was lyophilized from 10 mM Tris, pH8.0, 30 mM sodium chloride.

Purity/Purification

Molecular Biology Grade
98% by SDS-PAGE and HPLC.

Preparation and Storage

-20 degree C
Stability: The lyophilized protein is stable for few weeks at room temperature, but best stored at -20 degree C. Reconstituted FGF-17 should be stored in working aliquots at -20 degree C. Freeze/thaw cycles will result in signi cant loss of activity.

Molecular Weight

24,891 Da

Chromosome Location

Chromosome: 8; NC_000008.10 (21900428..21906320). Location: 8p21

OMIM

603725

3D Structure

ModBase 3D Structure for O60258

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is 0.5ng/ml, corresponding to a speci c activity of 2 x 10e6 units/mg.

Country of Origin

USA

Endotoxin Level

0.1ng/ug (1EU/ug).

Reconstitution

We recommend a quick spin followed by reconstitution in 5mM Tris, pH 8.0 to a concentration of 0.1-1.0mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use.

Product Categories/Family for FGF17 active protein

Growth Factors; Cytokines; Growth Factors-FGF

Other Notes

Small volumes of FGF17 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF17 purchase

MBS650236 is an active protein targeting FGF17. Also known as Fibroblast Growth Factor 17, Recombinant, Human (FGF17). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF17. It may not necessarily be applicable to this product.

NCBI GI #

4503693

NCBI GeneID

8822

NCBI Accession #

NP_003858.1

UniProt Primary Accession #

O60258

UniProt Secondary Accession #

Q2M2W1; B7ZLG4

UniProt Related Accession #

O60258

GenBank Nucleotide #

NM_003867.2

NCBI Official Full Name

fibroblast growth factor 17

NCBI Official Synonym Full Names

fibroblast growth factor 17

NCBI Official Symbol

FGF17

NCBI Official Synonym Symbols

FGF-13

UniProt Protein Name

Fibroblast growth factor 17

Protein Family

Fibroblast growth factor

UniProt Gene Name

FGF17

UniProt Entry Name

FGF17_HUMAN

NCBI Protein Information

fibroblast growth factor 17; FGF-17; OTTHUMP00000122553; OTTHUMP00000224730

NCBI Summary for FGF17

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its amino acid sequence and chromosomal localization are identical to FGF17. [provided by RefSeq]

UniProt Comments for FGF17

Function: May be a signaling molecule in the induction and patterning of the embryonic brain.

Subcellular location: Secreted.

Tissue specificity: Preferentially expressed in the embryonic brain.

Developmental stage: Detected in embryos at E14.5, but not at E10.5 and E19.5. Preferentially expressed in the neuroepithelia of the isthmus and septum of the embryonic brain at E14.5.

Sequence similarities: Belongs to the heparin-binding growth factors family.

Research Articles on FGF17

1. FGF8, FGF17, and FGF18 are involved in autocrine and paracrine signaling in HCC and enhance the survival of tumor cells under stress conditions, malignant behavior, and neoangiogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF17 active protein

Reference Product	PubMed Publications
FGFR3 active protein	>5 publications with FGF17 and FGFR3
FGFR2 active protein	>5 publications with FGF17 and FGFR2
FGFR1 active protein	>5 publications with FGF17 and FGFR1
FGFR4 active protein	>3 publications with FGF17 and FGFR4

Pathways associated with FGF17 active protein

Products by Pathway	Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
FGFR Ligand Binding And Activation Pathway antibodies	FGFR Ligand Binding And Activation Pathway Diagram
FGFR1 Ligand Binding And Activation Pathway antibodies	FGFR1 Ligand Binding And Activation Pathway Diagram
FGFR1c Ligand Binding And Activation Pathway antibodies	FGFR1c Ligand Binding And Activation Pathway Diagram
FGFR2 Ligand Binding And Activation Pathway antibodies	FGFR2 Ligand Binding And Activation Pathway Diagram
FGFR2c Ligand Binding And Activation Pathway antibodies	FGFR2c Ligand Binding And Activation Pathway Diagram
FGFR3 Ligand Binding And Activation Pathway antibodies	FGFR3 Ligand Binding And Activation Pathway Diagram
FGFR3b Ligand Binding And Activation Pathway antibodies	FGFR3b Ligand Binding And Activation Pathway Diagram
FGFR3c Ligand Binding And Activation Pathway antibodies	FGFR3c Ligand Binding And Activation Pathway Diagram
FGFR4 Ligand Binding And Activation Pathway antibodies	FGFR4 Ligand Binding And Activation Pathway Diagram

Diseases associated with FGF17 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>7 publications with FGF17 and Neoplasms
Skin Neoplasms Antibodies	>1 publications with FGF17 and Skin Neoplasms
Leukemia Antibodies	>1 publications with FGF17 and Leukemia
Liver Diseases Antibodies	>1 publications with FGF17 and Liver Diseases
Liver Neoplasms Antibodies	>1 publications with FGF17 and Liver Neoplasms
Limb Deformities, Congenital Antibodies	>1 publications with FGF17 and Limb Deformities, Congenital
Inflammation Antibodies	>1 publications with FGF17 and Inflammation
Nervous System Malformations Antibodies	>1 publications with FGF17 and Nervous System Malformations
Respiratory Tract Diseases Antibodies	>1 publications with FGF17 and Respiratory Tract Diseases
Craniofacial Abnormalities Antibodies	>1 publications with FGF17 and Craniofacial Abnormalities

Organs/Tissues associated with FGF17 active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>27 publications with FGF17 and Brain
Embryonic Tissue Antibodies	>12 publications with FGF17 and Embryonic Tissue