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Uridine Monophosphate Kinase 1 (URK1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6504852

MBS6504852 is an antibody targeting URK1. Also known as Uridine Monophosphate Kinase 1, NT (Cytidine monophosphokinase 1, UCK 1, Uridine-cytidine kinase 1, Uridine monophosphokinase 1, URK1) (Azide free) (HRP). Reactive in Human, Mouse. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Uridine Monophosphate Kinase 1 (URK1), Polyclonal Antibody
Full Product Name
Uridine Monophosphate Kinase 1, NT (Cytidine monophosphokinase 1, UCK 1, Uridine-cytidine kinase 1, Uridine monophosphokinase 1, URK1) (Azide free) (HRP)
Product Gene Name
anti-URK1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human UCK. Species Crossreactivity: mouse.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
22,222 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (47799469..47844511). Location: 1p32
OMIM
191710
3D Structure
ModBase 3D Structure for P30085
Immunogen
Synthetic peptide selected from the N-terminal region of human UCK (KLH).
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-URK1 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-URK1 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-URK1 antibody
IHC: 1:50-1:100
ELISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-URK1 antibody

The anti-UCK Pab is used in Western blot to detect UCK in mouse cerebellum tissue lysate (Lane 1) and HepG2 cell lysate (Lane 2).
Rabbit Anti-URK1 Polyclonal Antibody – Cat# MBS6504852

Immunohistochemistry (IHC) of anti-URK1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-URK1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6504852

Product References and Citations for anti-URK1 antibody

1. Strausberg, R.L., et al., Proc. Natl. Acad. Sci. USA 99(26):16899-16903 (2002). 2. Hu, R.M., et al., Proc. Natl. Acad. Sci. USA 97(17):9543-9548 (2000). 3. Hughes, G.J., et al., Electrophoresis 14(11):1216-1222 (1993). 4. Hochstrasser, D.F., et al., Electrophoresis 13(12):992-1001 (1992). 5. BD Zlatopolskiy, et al. J Nucl Med. 2009; 50: 1895. (Applications: IHC)(E-pub).

Other Notes

Small volumes of anti-URK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for URK1. It may not necessarily be applicable to this product.

NCBI GI #
209915597
NCBI GeneID
51727
NCBI Accession #
NP_001129612.1
UniProt Primary Accession #
P30085
UniProt Secondary Accession #
Q53GB7; Q5SVZ0; Q96C07; Q9UBQ8; Q9UIA2
UniProt Related Accession #
P30085
GenBank Nucleotide #
NM_001136140.1
NCBI Official Full Name
UMP-CMP kinase isoform b
NCBI Official Synonym Full Names
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
NCBI Official Symbol
CMPK1
NCBI Official Synonym Symbols
CK; CMK; UMK; CMPK; UMPK; UMP-CMPK; RP11-511I2.1
UniProt Protein Name
UMP-CMP kinase
UniProt Synonym Protein Names
Deoxycytidylate kinase; CK; dCMP kinase; Uridine monophosphate/cytidine monophosphate kinase
UniProt Gene Name
CMPK1
UniProt Synonym Gene Names
CMK; CMPK; UCK; UMK; UMPK; CK; dCMP kinase; UMP/CMP kinase; UMP/CMPK
UniProt Entry Name
KCY_HUMAN
NCBI Protein Information
UMP-CMP kinase; dCMP kinase; UMP/CMP kinase; cytidylate kinase; deoxycytidylate kinase; uridine monophosphate kinase; uridine monophosphate/cytidine monophosphate kinase

NCBI Summary for URK1

This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]
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UniProt Comments for URK1

CMPK: Catalyzes specific phosphoryl transfer from ATP to UMP and CMP. Belongs to the adenylate kinase family.

Protein type: EC 2.7.4.14; Nucleotide Metabolism - pyrimidine; Kinase, other; EC 2.7.4.6

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: nucleoplasm; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: uridine kinase activity; UMP kinase activity; nucleoside diphosphate kinase activity; cytidylate kinase activity; ATP binding

Biological Process: nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; UMP biosynthetic process; phthalate metabolic process; pyrimidine ribonucleotide biosynthetic process; nucleoside diphosphate phosphorylation; UDP biosynthetic process; ovulation cycle process; 'de novo' pyrimidine base biosynthetic process; CDP biosynthetic process; dUDP biosynthetic process; nucleoside triphosphate biosynthetic process; dCDP biosynthetic process
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Research Articles on URK1

1. In particular, polymorphisms of the CMPK1 gene seem to provide important prognostic information

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-URK1 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway antibodies  Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway Diagram
 Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway antibodies  Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway Diagram
 Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway antibodies  Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway Diagram
 UTP And CTP De Novo Biosynthesis Pathway antibodies  UTP And CTP De Novo Biosynthesis Pathway Diagram
 Pyrimidine Deoxyribonucleotide Phosphorylation Pathway antibodies  Pyrimidine Deoxyribonucleotide Phosphorylation Pathway Diagram
 Pyrimidine Ribonucleotides Interconversion Pathway antibodies  Pyrimidine Ribonucleotides Interconversion Pathway Diagram

Diseases associated with anti-URK1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with URK1 and Inflammation
 Necrosis Antibodies  >1 publications with URK1 and Necrosis

Organs/Tissues associated with anti-URK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with URK1 and Lung
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