Transforming Growth Factor Beta2 (TGFB2) Active Protein

Name: TGFB2 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS650502
Price: 665 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650502

TGF-B is a multifunctional polypeptide growth factor. While specific receptors for this protein have been found on almost all mammalian cell types, the effect of the molecule varies depending on the cell type and growth conditions. Generally, TGF-B is… More details

$665 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Transforming Growth Factor beta2 (TGFB2), Active Protein

Full Product Name

Transforming Growth Factor beta2, Recombinant, Human (TGFb2, Polyergin, Cetermin, G-TSF, Glioblastoma-derived T-cell suppressor factor, BSC-1 cell growth inhibitor)

Product Gene Name

TGFB2 active protein

Form/Format

Supplied as a lyophilized powder from sodium citrate buffer, pH 3.5. Sterile filtered prior to lyophilization. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml. Do not vortex.

Purity/Purification

Highly Purified
~98% (SDS-PAGE, HPLC). Purified by sequential chromatography.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

25.0kD, 112 amino acid residues

Chromosome Location

Chromosome: 1; NC_000001.10 (218519391..218617961). Location: 1q41

OMIM

190220

3D Structure

ModBase 3D Structure for P61812

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

ED50 0.2ng/ml (5x10e6units/mg), determined by its ability to inhibit the mouse IL-4 dependent proliferation of mouse HT-2 cells. TGF-b2 has growth inhibitory action and regulates the proliferation and differentiation of normal and transformed cells. Differential expression of TGF isoforms is observed in certain disease states. Human PC-3 prostatic carcinoma cell line and human glioblastoma cell lines predominantly secrete the TGF-b2 isoform over the other isoforms.

Endotoxin Level

~0.1ng/ug

Product Categories/Family for TGFB2 active protein

Growth Factors; Cytokines; Growth Factors-TGF

Other Notes

Small volumes of TGFB2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGFB2 purchase

MBS650502 is an active protein targeting TGFB2. Also known as Transforming Growth Factor beta2, Recombinant, Human (TGFb2, Polyergin, Cetermin, G-TSF, Glioblastoma-derived T-cell suppressor factor, BSC-1 cell growth inhibitor).

Additional Details

NCBI/Uniprot data below describe general gene information for TGFB2. It may not necessarily be applicable to this product.

NCBI GI #

557563

NCBI GeneID

7042

UniProt Primary Accession #

P61812

UniProt Secondary Accession #

P08112; Q15579; Q15581; Q4VAV9; B4DKC5

UniProt Related Accession #

P61812; Q59EG9

NCBI Official Full Name

transforming growth factor beta 2

NCBI Official Synonym Full Names

transforming growth factor, beta 2

NCBI Official Symbol

TGFB2

NCBI Official Synonym Symbols

MGC116892; TGF-beta2

UniProt Protein Name

Transforming growth factor beta-2

UniProt Synonym Protein Names

BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; Polyergin

Protein Family

Transforming growth factor

UniProt Gene Name

TGFB2

UniProt Entry Name

TGFB2_HUMAN

NCBI Protein Information

transforming growth factor beta-2; G-TSF; cetermin; polyergin; TGF-beta-2; OTTHUMP00000037528; OTTHUMP00000037529; BSC-1 cell growth inhibitor; glioblastoma-derived T-cell suppressor factor

NCBI Summary for TGFB2

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

UniProt Comments for TGFB2

Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

Subunit structure: Homodimer; disulfide-linked. Interacts with ASPN. Ref.11

Subcellular location: Secreted.

Involvement in disease: Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.

Sequence similarities: Belongs to the TGF-beta family.

Research Articles on TGFB2

1. Carbachol can promote and atropine can inhibit the expression and secretion of TGF-beta2 in human retinal pigment epithelium cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGFB2 active protein

Reference Product	PubMed Publications
TGFB1 active protein	>895 publications with TGFB2 and TGFB1
TGFB3 active protein	>497 publications with TGFB2 and TGFB3
CTGF active protein	>39 publications with TGFB2 and CTGF
TGFBR3 active protein	>39 publications with TGFB2 and TGFBR3

Pathways associated with TGFB2 active protein

Products by Pathway	Pathway Diagram
ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chronic Myeloid Leukemia Pathway antibodies	Chronic Myeloid Leukemia Pathway Diagram
Chronic Myeloid Leukemia Pathway antibodies	Chronic Myeloid Leukemia Pathway Diagram
Colorectal Cancer Pathway antibodies	Colorectal Cancer Pathway Diagram

Diseases associated with TGFB2 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>288 publications with TGFB2 and Neoplasms
Fibrosis Antibodies	>211 publications with TGFB2 and Fibrosis
Inflammation Antibodies	>129 publications with TGFB2 and Inflammation
Carcinoma Antibodies	>114 publications with TGFB2 and Carcinoma
Skin Diseases Antibodies	>98 publications with TGFB2 and Skin Diseases
Cardiovascular Diseases Antibodies	>79 publications with TGFB2 and Cardiovascular Diseases
Lung Diseases Antibodies	>64 publications with TGFB2 and Lung Diseases
Adenocarcinoma Antibodies	>48 publications with TGFB2 and Adenocarcinoma
Cataract Antibodies	>47 publications with TGFB2 and Cataract
Autoimmune Diseases Antibodies	>43 publications with TGFB2 and Autoimmune Diseases

Organs/Tissues associated with TGFB2 active protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>334 publications with TGFB2 and Eye
Bone Antibodies	>243 publications with TGFB2 and Bone
Muscle Antibodies	>213 publications with TGFB2 and Muscle
Vascular Antibodies	>199 publications with TGFB2 and Vascular
Connective Tissue Antibodies	>172 publications with TGFB2 and Connective Tissue
Embryonic Tissue Antibodies	>135 publications with TGFB2 and Embryonic Tissue
Brain Antibodies	>128 publications with TGFB2 and Brain
Skin Antibodies	>127 publications with TGFB2 and Skin
Lung Antibodies	>121 publications with TGFB2 and Lung
Kidney Antibodies	>74 publications with TGFB2 and Kidney