Fibroblast Growth Factor 5 (FGF5) Active Protein

Name: FGF5 Active Protein; Fibroblast Growth Factor 5; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS650544
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650544

Fibroblast Growth Factor-5 is a heparin binding growth factor that stimulates the proliferation and activation of cells that express FGF receptors. Recombinant Human FGF-5 is a 27.5kD protein containing 252 amino residues. More details

$370 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Fibroblast Growth Factor 5 (FGF5), Active Protein

Full Product Name

Fibroblast Growth Factor 5, Recombinant, Human (FGF5)

Product Gene Name

FGF5 active protein

Host

E Coli

Form/Format

Supplied as a lyophilized powder from PBS, pH 7.2.

Purity/Purification

Molecular Biology Grade
98% by SDS-PAGE and HPLC.

Preparation and Storage

Lyophilized powder may be stored at RT/4 degree C for short-term only. Reconstitute to nominal volume by adding sterile PBS, aliquot and store at -20 degree C. Reconstituted product is stable for 12-12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

29,551 Da

Chromosome Location

Chromosome: 4; NC_000004.11 (81187742..81212171). Location: 4q21

OMIM

165190

3D Structure

ModBase 3D Structure for P12034

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is 0.5ng/ml, corresponding to a speci c activity of 2x10e6u/mg.

Country of Origin

USA

Endotoxin Level

0.1ng/ug (1EU/ug).

Reconstitution

Reconstitute in PBS to a concentration of 0.1-1mg/ml.

Product Categories/Family for FGF5 active protein

Growth Factors; Cytokines; Growth Factors-FGF

Other Notes

Small volumes of FGF5 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF5 purchase

MBS650544 is an active protein targeting FGF5. Also known as Fibroblast Growth Factor 5, Recombinant, Human (FGF5). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF5. It may not necessarily be applicable to this product.

NCBI GI #

182545

NCBI GeneID

2250

UniProt Primary Accession #

P12034

UniProt Secondary Accession #

O75846; Q3Y8M3; B2R554

UniProt Related Accession #

P12034; Q6A549; Q8NBG6; Q8NF90

NCBI Official Full Name

fibroblast growth factor 5

NCBI Official Synonym Full Names

fibroblast growth factor 5

NCBI Official Symbol

FGF5

NCBI Official Synonym Symbols

HBGF-5; Smag-82

UniProt Protein Name

Fibroblast growth factor 5

UniProt Synonym Protein Names

Heparin-binding growth factor 5; HBGF-5; Smag-82

Protein Family

Fibroblast growth factor

UniProt Gene Name

FGF5

UniProt Entry Name

FGF5_HUMAN

NCBI Protein Information

fibroblast growth factor 5; OTTHUMP00000160795; OTTHUMP00000160796; heparin-binding growth factor 5

NCBI Summary for FGF5

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

UniProt Comments for FGF5

Function: Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase

Subcellular location: Secreted

Potential.

Tissue specificity: Expressed in neonatal brain.

Developmental stage: Can transform NIH 3T3 cells.

Sequence similarities: Belongs to the heparin-binding growth factors family.

Sequence caution: The sequence AAB60698.1 differs from that shown. Reason: Erroneous gene model prediction.

Research Articles on FGF5

1. Variants in or near FGF5, CYP17A1 and MTHFR contributed to variation in BP and hypertension risk. Effect sizes of these three loci tended to be larger in Chinese than in white Europeans

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF5 active protein

Reference Product	PubMed Publications
FGFR1 active protein	>15 publications with FGF5 and FGFR1
FGFR2 active protein	>8 publications with FGF5 and FGFR2
FGFR4 active protein	>5 publications with FGF5 and FGFR4
FGFR3 active protein	>4 publications with FGF5 and FGFR3

Pathways associated with FGF5 active protein

Products by Pathway	Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
FGFR Ligand Binding And Activation Pathway antibodies	FGFR Ligand Binding And Activation Pathway Diagram
FGFR1 Ligand Binding And Activation Pathway antibodies	FGFR1 Ligand Binding And Activation Pathway Diagram
FGFR1c Ligand Binding And Activation Pathway antibodies	FGFR1c Ligand Binding And Activation Pathway Diagram
FGFR2 Ligand Binding And Activation Pathway antibodies	FGFR2 Ligand Binding And Activation Pathway Diagram
FGFR2c Ligand Binding And Activation Pathway antibodies	FGFR2c Ligand Binding And Activation Pathway Diagram
FGFR3 Ligand Binding And Activation Pathway antibodies	FGFR3 Ligand Binding And Activation Pathway Diagram
FGFR3c Ligand Binding And Activation Pathway antibodies	FGFR3c Ligand Binding And Activation Pathway Diagram
FRS2-mediated Cascade Pathway antibodies	FRS2-mediated Cascade Pathway Diagram
IRS-mediated Signalling Pathway antibodies	IRS-mediated Signalling Pathway Diagram

Diseases associated with FGF5 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>20 publications with FGF5 and Neoplasms
Cardiovascular Diseases Antibodies	>15 publications with FGF5 and Cardiovascular Diseases
Vascular Diseases Antibodies	>15 publications with FGF5 and Vascular Diseases
Skin Diseases Antibodies	>9 publications with FGF5 and Skin Diseases
Hypertension Antibodies	>7 publications with FGF5 and Hypertension
Heart Diseases Antibodies	>6 publications with FGF5 and Heart Diseases
Melanoma Antibodies	>4 publications with FGF5 and Melanoma
Adenocarcinoma Antibodies	>4 publications with FGF5 and Adenocarcinoma
Kidney Diseases Antibodies	>4 publications with FGF5 and Kidney Diseases
Cell Transformation, Neoplastic Antibodies	>4 publications with FGF5 and Cell Transformation, Neoplastic

Organs/Tissues associated with FGF5 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>22 publications with FGF5 and Blood
Skin Antibodies	>18 publications with FGF5 and Skin
Embryonic Tissue Antibodies	>15 publications with FGF5 and Embryonic Tissue
Muscle Antibodies	>14 publications with FGF5 and Muscle
Brain Antibodies	>13 publications with FGF5 and Brain
Bone Antibodies	>6 publications with FGF5 and Bone
Kidney Antibodies	>5 publications with FGF5 and Kidney
Connective Tissue Antibodies	>2 publications with FGF5 and Connective Tissue
Liver Antibodies	>1 publications with FGF5 and Liver