I-309 (CCL1) Active Protein

Name: CCL1 Active Protein; I-309; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS650555
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650555

The human cytokine I-309 is a small glycoprotein secreted by activated T lymphocytes and structurally related to a number of inflammatory cytokines. Recombinant Human I-309 is a single,non-glycosylated, polypeptide chain containing 74 amino acids and having a… More details

$370 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

I-309 (CCL1), Active Protein

Full Product Name

I-309, Recombinant, Human

Product Gene Name

CCL1 active protein

Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Lys-Se r-Met-Gln.

Host

E Coli

Form/Format

Supplied as a lyophilized powder. No additives.

Purity/Purification

Highly Purified
98% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

3,266 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (32687399..32690252, complement). Location: 17q12

3D Structure

ModBase 3D Structure for Q76BR7

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Human I-309 is fully biologically active when compared to standard. The Biological activity is calculated by its ability to chemoattract human T cells at 10.0-100.0ng/ml.

Dimers and Aggregates

1% as determined by silver-stained SDS-PAGE gel analysis.

Endotoxin Level

0.1ng/ug (IEU/ug) of Human HCC-1.

Protein Content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280nm.
2. Analysis by RP-HPLC, using a calibrated solution of Human I-309 as a Reference Standard.

Reconstitution

Reconstitute the lyophilized Human I-309 in sterile 18MO-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for CCL1 active protein

Growth Factors; Cytokines; Growth Factors-I-309

Other Notes

Small volumes of CCL1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL1 purchase

MBS650555 is an active protein targeting CCL1. Also known as I-309, Recombinant, Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL1. It may not necessarily be applicable to this product.

NCBI GI #

37360916

NCBI GeneID

6346

UniProt Primary Accession #

Q76BR7

UniProt Related Accession #

P22362; Q76BR7

NCBI Official Full Name

I-309

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 1

NCBI Official Symbol

CCL1

NCBI Official Synonym Symbols

P500; SISe; TCA3; I-309; SCYA1

UniProt Protein Name

I-309

Protein Family

C-C motif chemokine

UniProt Gene Name

SCYA1

UniProt Entry Name

Q76BR7_HUMAN

NCBI Protein Information

C-C motif chemokine 1; OTTHUMP00000163800; inflammatory cytokine I-309; small-inducible cytokine A1; T lymphocyte-secreted protein I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3)

NCBI Summary for CCL1

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine receptor CCR8. [provided by RefSeq]

UniProt Comments for CCL1

CCL1: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Chemokine

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function: chemokine activity

Biological Process: cellular calcium ion homeostasis; viral reproduction; immune response; signal transduction; chemotaxis

Research Articles on CCL1

1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL1 active protein

Reference Product	PubMed Publications
CCR8 active protein	>81 publications with CCL1 and CCR8

Pathways associated with CCL1 active protein

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with CCL1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>44 publications with CCL1 and Inflammation
Skin Diseases Antibodies	>19 publications with CCL1 and Skin Diseases
Nervous System Diseases Antibodies	>17 publications with CCL1 and Nervous System Diseases
Neoplasms Antibodies	>16 publications with CCL1 and Neoplasms
Asthma Antibodies	>15 publications with CCL1 and Asthma
Vascular Diseases Antibodies	>9 publications with CCL1 and Vascular Diseases
Cardiovascular Diseases Antibodies	>8 publications with CCL1 and Cardiovascular Diseases
Encephalomyelitis, Autoimmune, Experimental Antibodies	>8 publications with CCL1 and Encephalomyelitis, Autoimmune, Experimental
Leukemia Antibodies	>5 publications with CCL1 and Leukemia
Breast Neoplasms Antibodies	>4 publications with CCL1 and Breast Neoplasms

Organs/Tissues associated with CCL1 active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>18 publications with CCL1 and Lung