VEGF Receptor 1 (VEGFR1) Antibody – Rabbit Polyclonal

Angiogenesis, the formation of new blood vessels, is regulated by the balance between positive and negative endothelial regulatory factors. Vascular endothelial factor receptor-1 (VEGFR-1), also known as FMS-like tyrosine kinase 1 (Flt-1), is a transmembrane receptor tyrosine kinase with high affinity for vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) (1-3). Binding of VEGF to VEGFR-1 produces receptor dimerization and subsequent signal transduction. Full length VEGFR-1 is characterized by the presence of seven extracellular immunoglobulin-like domains containing the ligand binding region, a single short transmembrane sequence, and an intracellular region with a tyrosine kinase domain (2). VEGF receptors are expressed by vascular endothelial cells and peripheral blood monocytes (4), and have also been observed in colon carcinoma cell lines and colorectal cancer liver metastases (5). In addition to the full-length form of the receptor, a soluble form (sVEGFR-1 or sFlt-1) is generated by alternative splicing of Flt-1 mRNA. This naturally occurring, soluble form of VEGFR-1 is truncated on the C-terminal side of the sixth extracellular Ig-like domain (6), and has been described in various locations, including the serum and plasma of normal males and females, the serum of pregnant women, placenta, and breast tumor tissues (7,8). Soluble VEGFR-1 is an antagonist of VEGF action and an inhibitor of the VEGF signaling pathway, which has been characterized as one of the most important endothelial regulators in human tumor angiogenesis.

1. Devries C, et al. Science 255:989-991, 1992. 2. Thomas KA. J Biol Chem 271(2):603-606, 1996. 3. Neufeld G, et al. FASEB J 13:9-22, 1999. 4. Sawano A, et al. Blood 97(3):785-791, 2001. 5. Warren RS, et al. J Clin Invest 95(4):1789-1797, 1995. 6. Kendall R, Thomas KA. PNAS 90:10705-10709, 1993. 7. Barleon B, et al. Angiogenesis 4(2):143-154, 2001. 8. Toi M, et al. Int J Cancer 98(1):14-18, 2002. 9. Hornig C, et al. Lab Invest 80(4):443-454, 2000.

Small volumes of anti-VEGFR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6505588 is an antibody targeting VEGFR1. Also known as VEGF Receptor 1 (Flt1, VEGFR1) Soluble (Vascular Endothelial Growth Factor Receptor 1, sVEGFR-1, sFlt1) (FITC). Reactive in Human. Host: Rabbit.