Interleukin 9 (IL9) Active Protein

Name: IL9 Active Protein; Interleukin 9; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS650622
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650622

Interleukin (IL)-9 is known to regulate many cell types involved in T-helper type 2 responses classically associated with asthma, including B- and T-lymphocytes, mast cells, eosinophils and epithelial cells. Growing evidence obtained from human genomic… More details

$370 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 9 (IL9), Active Protein

Full Product Name

Interleukin 9, Recombinant, Mouse (IL-9)

Product Gene Name

IL9 active protein

Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Gln-Ar g-Cys-Ser.

Host

E Coli

Form/Format

Supplied as a lyophilized powder without additives.

Purity/Purification

Highly Purified
98% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

Preparation and Storage

-20 degree C
Stability: Lyophilized Murine Interleukin-9 although stable at room temperature for 3 weeks, should be stored desiccated below -180C. Upon reconstitution rhIL-9 should be stored at 40C between 2-7 days and for future use below -180C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

Molecular Weight

14.17kD

Chromosome Location

Chromosome: 5; NC_000005.9 (135227935..135231516, complement). Location: 5q31.1

OMIM

146931

3D Structure

ModBase 3D Structure for P15248

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Recombinant Murine IL-9 is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of human MO7e cells is < 0.5 ng/ml, corresponding to a Specific Activity of 2 x 106 IU/mg.

Dimers and Aggregates

1% as determined by silver-stained SDS-PAGE gel analysis.

Endotoxin Level

0.1ng/ug (IEU/ug) of Murine IL-9.

Protein Content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm using the absorbency value of 0.6 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
2. Analysis by RP-HPLC, using a standard solution of IL-9 as a Reference Standard.

Solubility

It is recommended to reconstitute the lyophilized Recombinant IL-9 in sterile 18M -cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for IL9 active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

Other Notes

Small volumes of IL9 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL9 purchase

MBS650622 is an active protein targeting IL9. Also known as Interleukin 9, Recombinant, Mouse (IL-9). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL9. It may not necessarily be applicable to this product.

NCBI GI #

10834980

NCBI GeneID

3578

NCBI Accession #

NP_000581.1

UniProt Primary Accession #

P15248

UniProt Related Accession #

P15248; Q6NZ74; Q6NZ75

GenBank Nucleotide #

NM_000590.1

NCBI Official Full Name

interleukin-9

NCBI Official Synonym Full Names

interleukin 9

NCBI Official Symbol

IL9

NCBI Official Synonym Symbols

P40; HP40; IL-9

UniProt Protein Name

Interleukin-9

UniProt Synonym Protein Names

Cytokine P40; T-cell growth factor P40

Protein Family

Interleukin

UniProt Gene Name

IL9

UniProt Entry Name

IL9_HUMAN

NCBI Protein Information

interleukin-9; cytokine P40; p40 cytokine; OTTHUMP00000159423; T-cell growth factor p40; p40 T-cell and mast cell growth factor; homolog of mouse T cell and mast cell growth factor 40

NCBI Summary for IL9

The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq]

UniProt Comments for IL9

Function: Supports IL-2 independent and IL-4 independent growth of helper T-cells.

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-7/IL-9 family.

Research Articles on IL9

1. analysis of IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL9 active protein

Reference Product	PubMed Publications
IL9R active protein	>3 publications with IL9 and IL9R
STAT5A active protein	>1 publications with IL9 and STAT5A

Pathways associated with IL9 active protein

Products by Pathway	Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
IL-9 Signaling Pathway antibodies	IL-9 Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with IL9 active protein

Disease Name	Pubmed Publications
Hypersensitivity Antibodies	>28 publications with IL9 and Hypersensitivity
Asthma Antibodies	>25 publications with IL9 and Asthma
Respiratory Tract Diseases Antibodies	>25 publications with IL9 and Respiratory Tract Diseases
Respiratory Hypersensitivity Antibodies	>23 publications with IL9 and Respiratory Hypersensitivity
Lung Diseases Antibodies	>23 publications with IL9 and Lung Diseases
Neoplasms Antibodies	>12 publications with IL9 and Neoplasms
Inflammation Antibodies	>11 publications with IL9 and Inflammation
Genetic Diseases, Inborn Antibodies	>6 publications with IL9 and Genetic Diseases, Inborn
Skin Diseases Antibodies	>4 publications with IL9 and Skin Diseases
Eye Diseases Antibodies	>3 publications with IL9 and Eye Diseases

Organs/Tissues associated with IL9 active protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>1 publications with IL9 and Kidney