Bone Morphogenetic Protein 7 (BMP7) Recombinant Protein

Bone Morphogenetic Proteins belong to the TGF-beta superfamily, whose members are widely represented throughout the animal kingdom. The BMPs are important regulators of key events in the processes of bone formation during embryogenesis, postnatal growth, remodeling and regeneration of the skeleton. The BMPs function by binding to a receptor complex that is found on all normal cells and is composed of type I and II receptors. The primary unit of bone formation is osteoblast, the bone-forming cell. These osteoblast cells respond to physical loading by transducing signals that alter gene expression patterns, and Cbfa (core binding factor), the osteoblast specific transcription factor plays an important role in osteoblast differentiation and function.

BMP7 or OP1, a 431-amino acid polypeptide that includes a secretory signal sequence, (Chr 20), is expressed in kidney, bladder and brain. Induces cartilage and bone formation may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. It plays a role in calcium regulation and bone homeostasis.

Small volumes of BMP7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS650711 is a recombinant protein targeting BMP7. Also known as Bone Morphogenetic Protein 7, Recombinant, Human, Western Blot Positive Control (BMP7).