Interleukin 6 Receptor (IL6R) Active Protein

Name: IL6R Active Protein; Interleukin 6 Receptor; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS650728
Price: 425 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650728

The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component speci c to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related… More details

$425 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 6 Receptor (IL6R), Active Protein

Full Product Name

Interleukin 6 Receptor, Recombinant, Human (IL-6R)

Product Gene Name

IL6R active protein

Host

HEK 293 cells

Form/Format

Supplied as a lyophilized powder from PBS, pH 7.2

Purity/Purification

Highly Purified
> or = 98% by SDS-PAGE and HPLC analyses

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Reconstitute in PBS, pH 7.2 to a concentration of 0.1-1.0mg/ml. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

37.6kD

Chromosome Location

Chromosome: 1; NC_000001.10 (154377669..154440188). Location: 1q21

OMIM

147880

3D Structure

ModBase 3D Structure for P08887

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< or = 0.1ng/ug (1EU/ug)

Reconstitution

Reconstitute in PBS, pH 7.2 to a concentration of 0.1-1.0mg/ml.

Biological Activity

The ED50 as determined by its' ability to intensify the IL-6induced groth inhibition of murin M1 cells is

Country of Origin

USA

Product Categories/Family for IL6R active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

Other Notes

Small volumes of IL6R active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL6R purchase

MBS650728 is an active protein targeting IL6R. Also known as Interleukin 6 Receptor, Recombinant, Human (IL-6R). Host: HEK 293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IL6R. It may not necessarily be applicable to this product.

NCBI GI #

32581

NCBI GeneID

3570

UniProt Primary Accession #

P08887

UniProt Secondary Accession #

Q16202; Q53EQ7; Q5FWG2; Q5VZ23; A8KAE8; B2R6V4

UniProt Related Accession #

P08887

NCBI Official Full Name

interleukin-6-receptor

NCBI Official Synonym Full Names

interleukin 6 receptor

NCBI Official Symbol

IL6R

NCBI Official Synonym Symbols

gp80; CD126; IL6RA; IL-6RA; IL-6R-1; MGC104991

UniProt Protein Name

Interleukin-6 receptor subunit alpha

UniProt Synonym Protein Names

IL-6R 1; Membrane glycoprotein 80

Protein Family

Interleukin-6 receptor

UniProt Gene Name

IL6R

UniProt Entry Name

IL6RA_HUMAN

NCBI Protein Information

interleukin-6 receptor subunit alpha; IL-6R 1; CD126 antigen; OTTHUMP00000034320; OTTHUMP00000217867; OTTHUMP00000217870; membrane glycoprotein 80; IL-6 receptor subunit alpha

NCBI Summary for IL6R

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

UniProt Comments for IL6R

Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Ref.13 Ref.14Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Ref.13 Ref.14

Subunit structure: Hexamer of two molecules each of IL6, IL6R and IL6ST.

Subcellular location: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein Ref.11 Ref.14. Isoform 2: Secreted Ref.11 Ref.14.

Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

Domain: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Post-translational modification: A short soluble form may also be released from the membrane by proteolysis.

Sequence similarities: Belongs to the type I cytokine receptor family. Type 3 subfamily.Contains 1 fibronectin type-III domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Research Articles on IL6R

1. Circulating sIL-6R and CD4+ IL-6R+ T cells were increased in chronic hepatitis B patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL6R active protein

Reference Product	PubMed Publications
IL6 active protein	>58 publications with IL6R and IL6
IL6ST active protein	>10 publications with IL6R and IL6ST
STAT3 active protein	>9 publications with IL6R and STAT3
SRC active protein	>1 publications with IL6R and SRC
CNTF active protein	>1 publications with IL6R and CNTF

Pathways associated with IL6R active protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
IL-6 Signaling Pathway antibodies	IL-6 Signaling Pathway Diagram
IL6-mediated Signaling Events Pathway antibodies	IL6-mediated Signaling Events Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interleukin-6 Signaling Pathway antibodies	Interleukin-6 Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with IL6R active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>30 publications with IL6R and Inflammation
Neoplasms Antibodies	>26 publications with IL6R and Neoplasms
Cardiovascular Diseases Antibodies	>16 publications with IL6R and Cardiovascular Diseases
Vascular Diseases Antibodies	>12 publications with IL6R and Vascular Diseases
Diabetes Mellitus Antibodies	>10 publications with IL6R and Diabetes Mellitus
Obesity Antibodies	>8 publications with IL6R and Obesity
Diabetes Mellitus, Type 2 Antibodies	>8 publications with IL6R and Diabetes Mellitus, Type 2
Lung Diseases Antibodies	>8 publications with IL6R and Lung Diseases
Adenocarcinoma Antibodies	>7 publications with IL6R and Adenocarcinoma
Multiple Myeloma Antibodies	>7 publications with IL6R and Multiple Myeloma

Organs/Tissues associated with IL6R active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>53 publications with IL6R and Blood
Vascular Antibodies	>12 publications with IL6R and Vascular
Heart Antibodies	>11 publications with IL6R and Heart
Kidney Antibodies	>9 publications with IL6R and Kidney
Liver Antibodies	>9 publications with IL6R and Liver
Bone Antibodies	>8 publications with IL6R and Bone
Muscle Antibodies	>6 publications with IL6R and Muscle
Brain Antibodies	>5 publications with IL6R and Brain
Lung Antibodies	>5 publications with IL6R and Lung
Bone Marrow Antibodies	>3 publications with IL6R and Bone Marrow