CTF1 Recombinant Protein – Cat# MBS650767

Cardiotrophin 1 (CTF1) Recombinant Protein

Name: CTF1 Recombinant Protein; Cardiotrophin 1; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS650767
Price: 680 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650767

Cardiotrophin-1 (CT-1) is a 201 amino acid member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. More details

$680 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cardiotrophin 1 (CTF1), Recombinant Protein

Full Product Name

Cardiotrophin 1, Human, Recombinant (CT1)

Product Gene Name

CTF1 recombinant protein

Sequence

MRGSHHHHHH GSSRREGSLE DPQTDSSVSL LPHLEAKIRQ THSLAHLLTK YAEQLLQEYV QLQGDPFGLP SFSPPRLPVA GLSAPAPSHA GLPVHERLRL DAAALAALPP LLDAVCRRQA ELNPRAPRLL RRLEDAARQA RALGAAVEAL LAALGAANRG PRAEPPAATA SAASATGVFP AKVLGLRVCG LYREWLSRTE GDLGQLLPGG SA.

Host

E Coli

Form/Format

Supplied as a lyophilized powder from 0.05M Acetate buffer pH4

Purity/Purification

Highly Purified
Three-step procedure using affinity Ni-NTA chromatography and size exclusion chromatography before and after refolding. Purity of recombinant human cardiotrophin is >90% (SDS-PAGE analyzed).

Specificity

The amino acid sequence of the recombinant human cardiotrophin is 100% homologous to the amino acid sequence of the human cardiotrophin.

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

22.5kD

Chromosome Location

Chromosome: 16; NC_000016.9 (30907928..30914881). Location: 16p11.2

OMIM

600435

3D Structure

ModBase 3D Structure for Q16619

Reconstitution

Add 0.2ml of 0.1M Acetate buffer pH4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of this antigen is limited.

Product Categories/Family for CTF1 recombinant protein

Growth Factors; Cytokines; Growth Factors-Cardiotrophin

Applications Tested/Suitable for CTF1 recombinant protein

Western Blot (WB)

Other Notes

Small volumes of CTF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTF1 purchase

MBS650767 is a recombinant protein targeting CTF1. Also known as Cardiotrophin 1, Human, Recombinant (CT1). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CTF1. It may not necessarily be applicable to this product.

NCBI GI #

4503121

NCBI GeneID

1489

NCBI Accession #

NP_001321.1

UniProt Primary Accession #

Q16619

UniProt Related Accession #

Q16619; Q5U5Y7

GenBank Nucleotide #

NM_001330.3

NCBI Official Full Name

cardiotrophin-1 isoform 1

NCBI Official Synonym Full Names

cardiotrophin 1

NCBI Official Symbol

CTF1

NCBI Official Synonym Symbols

CT1; CT-1

UniProt Protein Name

Cardiotrophin-1

Protein Family

Cardiotrophin

UniProt Gene Name

CTF1

UniProt Entry Name

CTF1_HUMAN

NCBI Protein Information

cardiotrophin-1; cardiophin 1; OTTHUMP00000163250

NCBI Summary for CTF1

The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProt Comments for CTF1

Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Subcellular location: Secreted.

Tissue specificity: Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

Sequence similarities: Belongs to the IL-6 superfamily.

Research Articles on CTF1

1. the 1742(C/G) polymorphism of the human CT-1 gene is associated with LVH in hypertension, and the GG genotype may have a protective role

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CTF1 recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies	MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram

Diseases associated with CTF1 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with CTF1 and Neoplasms
Thyroid Diseases Antibodies	>2 publications with CTF1 and Thyroid Diseases
Breast Neoplasms Antibodies	>1 publications with CTF1 and Breast Neoplasms
Cardiomegaly Antibodies	>1 publications with CTF1 and Cardiomegaly
Melanoma Antibodies	>1 publications with CTF1 and Melanoma
Carcinoma Antibodies	>1 publications with CTF1 and Carcinoma
Melanoma, Experimental Antibodies	>1 publications with CTF1 and Melanoma, Experimental
Weight Gain Antibodies	>1 publications with CTF1 and Weight Gain

Organs/Tissues associated with CTF1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with CTF1 and Brain
Nerve Antibodies	>1 publications with CTF1 and Nerve
Lung Antibodies	>1 publications with CTF1 and Lung