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IL-1 beta Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691678

IL-1beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological… More details

$305 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-1 beta, Active Protein
Full Product Name
Rat IL-1 beta
Product Gene Name
Product Synonym Names
Recombinant Rat IL-1 beta
Sequence
MVPIRQLHCR LRDEQQKCLV LSDPCELKAL HLNGQNISQQ VVFSMS FVQG ETSNDKIPVA LGLKGLNLYL SCVMKDGTPT LQLESVDPKQ Y PKKKMEKRF VFNKIEVKTK VEFESAQFPN WYISTSQAEH RPVFLGN SNG RDIVDFTMEP VSS
Host
E Coli
Species Reactivity
Rat
Form/Format
Lyophilized
Purity/Purification
> 98% by SDS-PAGE and HPLC analysis
Molecular Weight
17.3 kDa
Chromosome Location
Chromosome: 3; NC_005102.3 (128133929..128140354). Location: 3q36
3D Structure
ModBase 3D Structure for Q5BKB0
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng/ug of IL-1 beta
Biological Activity
The ED50 was determined by the dose-dependent stimulation of murine D10S cells is <= 0.1 ng/ml, corresponding to a specific activity of >= 1 x 107 units/mg.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of IL-1 beta active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-1 beta purchase

MBS691678 is an active protein targeting IL-1 beta. Also known as Rat IL-1 beta. Reactive in Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-1 beta. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-1 beta
NCBI Official Synonym Full Names
interleukin 1 beta
NCBI Official Symbol
Il1b
UniProt Protein Name
Interleukin 1 beta
Protein Family
UniProt Gene Name
Il1b
UniProt Entry Name
Q5BKB0_RAT
NCBI Protein Information
interleukin-1 beta; IL-1 beta

NCBI Summary for IL-1 beta

an inflammatory cytokine [RGD, Feb 2006]

UniProt Comments for IL-1 beta

Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells

By similarity. RuleBase RU003753

Subunit structure: Monomer

By similarity. RuleBase RU003753

Sequence similarities: Belongs to the IL-1 family. RuleBase RU003752
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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