Mouse Anti-PRSS2 Monoclonal Antibody – Cat# MBS6508387

Trypsin 2 (PRSS2) Antibody – Mouse Monoclonal

Name: PRSS2 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6508387
Price: 1045 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6508387

Trypsin 2 is a serine protease secreted by the pancreas and cleaved to its active form in the small intestine. Trypsin 2 consists of a signal peptide (residues 1-15), a pro region (residues 16-23), and a proteolytically active mature chain (residues 24-247).… More details

$1045 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Trypsin 2 (PRSS2), Monoclonal Antibody

Full Product Name

Trypsin 2 (PRSS2)

Product Gene Name

anti-PRSS2 antibody

Product Synonym Names

Trypsin 2

Clonality

Monoclonal

Isotype

IgG1

Clone Number

7H237

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.

Purity/Purification

Affinity Purified

Concentration

~0.5mg/ml (after reconstitution) (lot specific)

Specificity

Recognizes human Trypsin 2, both the pro and mature forms. Does not crossreact with rhTrypsin1 or rhTrypsin3.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute by adding sterile PBS. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

26,488 Da

OMIM

601564

3D Structure

ModBase 3D Structure for P07478

Immunogen

NS0-derived recombinant human Trypsin 2 encoded by the PRSS2 gene (Ala16-Ser247)

Species Sequence Homology

mouse and rat-78%.

Product Categories/Family for anti-PRSS2 antibody

Antibodies-Primary; Antibodies-Enzymes

Applications Tested/Suitable for anti-PRSS2 antibody

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

Application Notes for anti-PRSS2 antibody

Immunoprecipitation: 25ug/ml
Western Blot: 1-2ug/ml. The detection limit is ~10ng/well under non-reducing conditions.
Direct ELISA: 0.5-1ug/ml. The detection limit is ~2ng/well.

Other Notes

Small volumes of anti-PRSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRSS2 purchase

MBS6508387 is an antibody targeting PRSS2. Also known as Trypsin 2 (PRSS2). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PRSS2. It may not necessarily be applicable to this product.

NCBI GI #

119572308

NCBI GeneID

5645

NCBI Accession #

EAW51923.1

UniProt Primary Accession #

P07478

UniProt Related Accession #

P07478

NCBI Official Full Name

protease, serine, 2 (trypsin 2), isoform CRA_b

NCBI Official Synonym Full Names

protease, serine, 2 (trypsin 2)

NCBI Official Symbol

PRSS2

NCBI Official Synonym Symbols

TRY2; TRY8; TRYP2

UniProt Protein Name

Trypsin-2

UniProt Synonym Protein Names

Anionic trypsinogen; Serine protease 2; Trypsin II

Protein Family

Anionic trypsin

UniProt Gene Name

PRSS2

UniProt Synonym Gene Names

TRY2; TRYP2

UniProt Entry Name

TRY2_HUMAN

NCBI Protein Information

trypsin-2; trypsin 2; trypsin II; trypsinogen 2; serine protease 2; anionic trypsinogen; protease serine 2 preproprotein; protease, serine, 2, preproprotein

NCBI Summary for PRSS2

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

UniProt Comments for PRSS2

trypsin 2: In the ileum, may be involved in defensin processing, including DEFA5. Belongs to the peptidase S1 family.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide; Calcium-binding; EC 3.4.21.4; Protease; Cell adhesion

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; digestion; innate immune response; proteolysis; positive regulation of cell growth

Disease: Pancreatitis, Hereditary

Research Articles on PRSS2

1. Trypsin-1 and trypsin-2 appear to have a function in the degradation of vitreous type II collagen.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRSS2 antibody

Reference Product	PubMed Publications
MMP13 antibody	>2 publications with PRSS2 and MMP13
MMP3 antibody	>1 publications with PRSS2 and MMP3
MMP9 antibody	>1 publications with PRSS2 and MMP9

Pathways associated with anti-PRSS2 antibody

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Alpha-defensins Pathway antibodies	Alpha-defensins Pathway Diagram
Collagen Degradation Pathway antibodies	Collagen Degradation Pathway Diagram
Defensins Pathway antibodies	Defensins Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram

Diseases associated with anti-PRSS2 antibody

Disease Name	Pubmed Publications
Pancreatitis, Chronic Antibodies	>45 publications with PRSS2 and Pancreatitis, Chronic
Neoplasms Antibodies	>22 publications with PRSS2 and Neoplasms
Pain Antibodies	>17 publications with PRSS2 and Pain
Pancreatic Neoplasms Antibodies	>13 publications with PRSS2 and Pancreatic Neoplasms
Adenocarcinoma Antibodies	>10 publications with PRSS2 and Adenocarcinoma
Inflammation Antibodies	>8 publications with PRSS2 and Inflammation
Liver Neoplasms Antibodies	>2 publications with PRSS2 and Liver Neoplasms
Liver Cirrhosis Antibodies	>2 publications with PRSS2 and Liver Cirrhosis
Weight Gain Antibodies	>1 publications with PRSS2 and Weight Gain
Liver Diseases Antibodies	>1 publications with PRSS2 and Liver Diseases

Organs/Tissues associated with anti-PRSS2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>47 publications with PRSS2 and Blood
Pancreas Antibodies	>33 publications with PRSS2 and Pancreas
Intestine Antibodies	>4 publications with PRSS2 and Intestine
Liver Antibodies	>3 publications with PRSS2 and Liver
Testis Antibodies	>1 publications with PRSS2 and Testis