BD3 (DEFB3) Active Protein

Name: DEFB3 Active Protein; BD3; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS650863
Price: 665 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650863

Defensin beta 3 (BD-3) is a cationic non-haemolytic antimicrobial peptide and member of the beta-defensin family, highly expressed by skin and tonsils, which plays an important role in the innate immune response to potentially pathogenic microbes, including… More details

$665 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BD3 (Defb3), Active Protein

Full Product Name

BD3, Recombinant, Human (beta Defensin-3)

Product Gene Name

Defb3 active protein

Host

E Coli

Form/Format

Supplied as a lyophilized powder. Reconstitute with 200ul dH20.

Purity/Purification

Highly Purified
98% (SDS PAGE and HPLC).

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

5.1kD (45 amino acid residues)

Chromosome Location

Chromosome: 8; NC_000074.5 (19293361..19295339). Location: 8; 8

3D Structure

ModBase 3D Structure for Q9WTL0

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Exhibits antimicrobial activity against gram-positive bacteria S. aureus and gram-negative P. aeruginosa and E.coli.

Endotoxin Level

1EU/ug

Product Categories/Family for Defb3 active protein

Growth Factors; Cytokines; Growth Factors-Defensin

Application Notes for Defb3 active protein

Suitable for use in Functional Assays.

Other Notes

Small volumes of Defb3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Defb3 purchase

MBS650863 is an active protein targeting Defb3. Also known as BD3, Recombinant, Human (beta Defensin-3). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Defb3. It may not necessarily be applicable to this product.

NCBI GI #

7304997

NCBI GeneID

27358

NCBI Accession #

NP_038784.1

UniProt Primary Accession #

Q9WTL0

UniProt Secondary Accession #

Q29R78

UniProt Related Accession #

Q9WTL0

GenBank Nucleotide #

NM_013756.2

NCBI Official Full Name

beta-defensin 3

NCBI Official Synonym Full Names

defensin beta 3

NCBI Official Symbol

Defb3

NCBI Official Synonym Symbols

BD-3; MGC129397

UniProt Protein Name

Beta-defensin 3

UniProt Synonym Protein Names

Defensin, beta 3

Protein Family

Beta-defensin

UniProt Gene Name

Defb3

UniProt Synonym Gene Names

Bd3

UniProt Entry Name

DEFB3_MOUSE

NCBI Protein Information

beta-defensin 3; OTTMUSP00000022575

UniProt Comments for Defb3

Function: Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa. Ref.1

Subcellular location: Secreted.

Tissue specificity: Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue. Ref.1 Ref.3

Induction: By bacterial infection. Ref.1

Sequence similarities: Belongs to the beta-defensin family. LAP/TAP subfamily.

Research Articles on Defb3

1. Mouse beta-defensin 3 was strongly up-regulated in colonic epithelium of 15 (but not 5) week-old IL-2(-/-) mice and in dextran-sulfate-induced chronic (but not acute) colitis, but not in IL-2(+/-) 15-week-old mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Defb3 active protein

Disease Name	Pubmed Publications
Skin Abnormalities Antibodies	>1 publications with Defb3 and Skin Abnormalities
Musculoskeletal Diseases Antibodies	>1 publications with Defb3 and Musculoskeletal Diseases