GRO/Kc (CXCL1) Active Protein

Name: CXCL1 Active Protein; GRO/Kc; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS650941
Price: 750 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650941

KC is a member of the CXC chemokine family with homology to human IL-8, a potent neutrophilic chemotactic cytokine. KC is a fundamental mediator of neutrophil recruitment in acute mast cell-dependent skin inflammation.Recombinant murine KC also nown as N51… More details

$750 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GRO/KC (Cxcl1), Active Protein

Full Product Name

GRO/KC, Recombinant, Mouse (Cxcl1, Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, alpha), Cinc1, CINC-1, C-X-C Motif Chemokine 1, Cytokine-induced Neutrophil Chemoattractant 1, Gro1, Growth-regulated alpha Protein, Platelet-derive

Product Gene Name

Cxcl1 active protein

Product Synonym Names

Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-Il e-Ala-Asn.

Host

E Coli

Form/Format

Supplied as a lyophilized powder without additives.

Purity/Purification

Highly Purified
98% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

Preparation and Storage

-20 degree C
Stability: Lyophilized Murine N51/KC although stable at room temperature for 3 weeks, should be stored desiccated below -180C. Upon reconstitution GRO1 should be stored at 40C between 2-7 days and for future use below -180C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

Molecular Weight

7.82kD

Chromosome Location

Chromosome: 14; NC_005113.3 (18653032..18654811, complement). Location: 14p22

3D Structure

ModBase 3D Structure for P14095

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Mouse CXCL1 is fully biologically active when compared to standard. The Biological activity is calculated by its ability to chemoattract human neutrophils cells using a conc. of 10.0-100 ng/ml.

Dimers and Aggregates

Less than 1% as determined by silver-stained SDS-PAGE gel analysis.

Endotoxin Level

0.1ng/ug (IEU/ug) of Mouse KC

Protein Content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm using the absorbency value of 0.03 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
2. Analysis by RP-HPLC, using a standard solution of KC as a Reference Standard.rietary chromatographic techniques.

Solubility

It is recommended to reconstitute the lyophilized Recombinant GRO1 in sterile 18M -cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for Cxcl1 active protein

Growth Factors; Cytokines; Growth Factors-GRO

Other Notes

Small volumes of Cxcl1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cxcl1 purchase

MBS650941 is an active protein targeting Cxcl1. Also known as GRO/KC, Recombinant, Mouse (Cxcl1, Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, alpha), Cinc1, CINC-1, C-X-C Motif Chemokine 1, Cytokine-induced Neutrophil Chemoattractant 1, Gro1, Growth-regulated alpha Protein, Platelet-derive. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Cxcl1. It may not necessarily be applicable to this product.

NCBI GI #

13540652

NCBI GeneID

81503

NCBI Accession #

NP_110472.1

UniProt Primary Accession #

P14095

UniProt Related Accession #

P14095

GenBank Nucleotide #

NM_030845.1

NCBI Official Full Name

growth-regulated alpha protein

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 1

NCBI Official Symbol

Cxcl1

NCBI Official Synonym Symbols

Gro1; CINC-1

UniProt Protein Name

Growth-regulated alpha protein

UniProt Synonym Protein Names

C-X-C motif chemokine 1; Cytokine-induced neutrophil chemoattractant 1; CINC-1; Platelet-derived growth factor-inducible protein KC

Protein Family

Growth-regulated alpha protein

UniProt Gene Name

Cxcl1

UniProt Synonym Gene Names

Cinc1; Gro; Scyb1; CINC-1

UniProt Entry Name

GROA_RAT

NCBI Protein Information

growth-regulated alpha protein; C-X-C motif chemokine 1; cytokine-induced neutrophil chemoattractant 1; platelet-derived growth factor-inducible protein KC; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

NCBI Summary for Cxcl1

acts as a neutrophil chemoattractant; may play a role in acute phase inflammatory response [RGD, Feb 2006]

UniProt Comments for Cxcl1

Function: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation.

Subunit structure: Monomer and homodimer.

Subcellular location: Secreted.

Tissue specificity: At least expressed in the lung and trachea.

Induction: By lipopolysaccharides (LPS) and inflammation.

Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.

Research Articles on Cxcl1

1. Function of the transient receptor potential vanilloid (TRPV)1 channel is enhanced by dorsal root ganglia inflammation. The effects (decreased tachyphylaxis) are mimicked by incubation with GRO/KC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Cxcl1 active protein

Reference Product	PubMed Publications
Cxcl2 active protein	>486 publications with Cxcl1 and Cxcl2
Ccl2 active protein	>461 publications with Cxcl1 and Ccl2
Il8rb active protein	>202 publications with Cxcl1 and Il8rb
Cxcl3 active protein	>83 publications with Cxcl1 and Cxcl3
Cxcl6 active protein	>65 publications with Cxcl1 and Cxcl6
Cxcr4 active protein	>46 publications with Cxcl1 and Cxcr4
Il6 active protein	>41 publications with Cxcl1 and Il6
Ccr2 active protein	>36 publications with Cxcl1 and Ccr2
Cxcr3 active protein	>29 publications with Cxcl1 and Cxcr3
Ppbp active protein	>21 publications with Cxcl1 and Ppbp

Pathways associated with Cxcl1 active protein

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokines And Inflammatory Response (BioCarta) Pathway antibodies	Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
Legionellosis Pathway antibodies	Legionellosis Pathway Diagram
Legionellosis Pathway antibodies	Legionellosis Pathway Diagram
NOD-like Receptor Signaling Pathway antibodies	NOD-like Receptor Signaling Pathway Diagram
NOD-like Receptor Signaling Pathway antibodies	NOD-like Receptor Signaling Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram
Spinal Cord Injury Pathway antibodies	Spinal Cord Injury Pathway Diagram

Diseases associated with Cxcl1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>958 publications with Cxcl1 and Inflammation
Necrosis Antibodies	>486 publications with Cxcl1 and Necrosis
Disease Models, Animal Antibodies	>352 publications with Cxcl1 and Disease Models, Animal
Lung Diseases Antibodies	>286 publications with Cxcl1 and Lung Diseases
Neoplasms Antibodies	>282 publications with Cxcl1 and Neoplasms
Cardiovascular Diseases Antibodies	>163 publications with Cxcl1 and Cardiovascular Diseases
Lung Injury Antibodies	>156 publications with Cxcl1 and Lung Injury
Pneumonia Antibodies	>101 publications with Cxcl1 and Pneumonia
Wounds and Injuries Antibodies	>87 publications with Cxcl1 and Wounds and Injuries
Reperfusion Injury Antibodies	>84 publications with Cxcl1 and Reperfusion Injury

Organs/Tissues associated with Cxcl1 active protein

Organ/Tissue Name	Pubmed Publications
Pancreas Antibodies	>27 publications with Cxcl1 and Pancreas