Interleukin 1 Beta, Rat (IL1B) Active Protein

Name: IL1B Active Protein; Interleukin 1 Beta, Rat; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS650942
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650942

Interleukin-1beta (IL-1beta) is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T cells. Rat IL-1 is a 17.3kD protein containing 153 amino acid residues. More details

$370 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 1 beta, Rat (IL1B), Active Protein

Full Product Name

Interleukin 1 beta, Recombinant, Rat (IL-1b)

Product Gene Name

IL1B active protein

Sequence

MVPIRQLHCR LRDEQQKCLV LSDPCELKAL HLNGQNISQQ VVFSMSFVQG ETSNDKIPVA LGLKGLNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKTK VEFESAQFPN WYISTSQAEH RPVFLGNSNG RDIVDFTMEP VSS

Host

E Coli

Form/Format

Supplied as a lyophilized powder from sterile-filtered 4mM Tris, pH 8.0, without additives. Reconstitute with sterile dH2O, carrier protein to concentration of 0.1-1mg/ml.

Purity/Purification

Highly Purified
98% by SDS-PAGE and HPLC analyses Endotoxin: 0.1ng/ug

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute by adding sterile ddH2O, protein carrier. Aliquot and store at -20 degree C. Reconstituted protein is stable for 3 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

17.3kD

Chromosome Location

Chromosome: 2; NC_013670.1 (97614341..97618580, complement)

3D Structure

ModBase 3D Structure for P14628

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

The ED50 of Rat IL-1beta as determined by the dose-dependent stimulation of murine D10S cells is 0.1ng/ml, corresponding to a specific activity of 1x10e7 units/mg.

Reconstitution

Lyophilized rat IL-1beta is soluble in water and most aqueous buffers. The lyophilized protein can be reconstituted in water to a concentration of 0.1-1.0mg/ml. This solution can be diluted into other buffered solutions or stored at- 20 degree C for future use.

Product Categories/Family for IL1B active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

Other Notes

Small volumes of IL1B active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL1B purchase

MBS650942 is an active protein targeting IL1B. Also known as Interleukin 1 beta, Recombinant, Rat (IL-1b). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL1B. It may not necessarily be applicable to this product.

NCBI GI #

126723555

NCBI GeneID

100008990

NCBI Accession #

NP_001075670.1

UniProt Primary Accession #

P14628

UniProt Related Accession #

P14628

GenBank Nucleotide #

NM_001082201.1

NCBI Official Full Name

interleukin-1 beta

NCBI Official Symbol

IL1B

NCBI Official Synonym Symbols

IL1-BETA

UniProt Protein Name

Interleukin-1 beta

UniProt Synonym Protein Names

Lymphocyte proliferation-potentiating factor

Protein Family

Interleukin

UniProt Gene Name

IL1B

UniProt Entry Name

IL1B_RABIT

NCBI Protein Information

interleukin-1 beta; IL-1 beta; interleukin 1 beta; lymphocyte proliferation-potentiating factor

UniProt Comments for IL1B

Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Subunit structure: Monomer.

Subcellular location: Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similarities: Belongs to the IL-1 family.

Research Articles on IL1B

1. IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic ...

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with IL1B active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>125 publications with IL1B and Inflammation
Necrosis Antibodies	>98 publications with IL1B and Necrosis
Neoplasms Antibodies	>80 publications with IL1B and Neoplasms
Lung Diseases Antibodies	>36 publications with IL1B and Lung Diseases
Stomach Neoplasms Antibodies	>26 publications with IL1B and Stomach Neoplasms
Skin Diseases Antibodies	>24 publications with IL1B and Skin Diseases
Cardiovascular Diseases Antibodies	>23 publications with IL1B and Cardiovascular Diseases
Intestinal Diseases Antibodies	>21 publications with IL1B and Intestinal Diseases
Osteoarthritis Antibodies	>20 publications with IL1B and Osteoarthritis
Arthritis, Rheumatoid Antibodies	>18 publications with IL1B and Arthritis, Rheumatoid