ORL1 Agonist

Synthetic peptide CKTSETVPRPA (linear).

ORL1 shares functional and structural homology to the opioid receptor system, but does not interact directly with classical opioid receptors or ligands. Rather, it appears to be the endogenous receptor for nociceptin/Orphanin FQ. This peptide binds the receptor with very high affinity. Activation of ORL1 receptors is functionally complex. For example, depending on its site of activation in the pain pathway, ORL1 has opposing actions, where it appears to have potent anti-analgesic actions supraspinally and analgesic actions spinally. In addition to its involvement in sensory perception, ORL1 has also been shown to play a role in memory processes and emotional behavior.
See corresponding antibody O7900

Small volumes of ORL1 agonist vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS651135 is an agonist targeting ORL1. Reactive in Human, Mouse, Rat.