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Hyaluronidase, Bovine, Highly Purified (HYAL3) Enzyme

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS653746

Hyaluronidase catalyzes the random hydrolysis of 1,4-linkages between 2-acetamido-2-deoxy-beta-D-glucose and D-glucose residues in hyaluronate. Hyaluronate 4-glycanohydrolase (EC 3.2.1.35) catalyzes the depolymerization of mucopolysaccharides, hyaluronic… More details

$530 / 5000 Units +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Hyaluronidase, Bovine, Highly Purified (HYAL3), Enzyme
Full Product Name
Hyaluronidase, Bovine, Highly Purified
Product Gene Name
HYAL3 enzyme
Host
Bovine testes
Form/Format
Supplied as a dialyzed, lyophilized powder
Purity/Purification
Molecular Biology Grade
Chromatographically purified
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Prepare fresh before use..
Molecular Weight
46,501 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (50330259..50336899, complement). Location: 3p21.3
OMIM
604038
3D Structure
ModBase 3D Structure for O43820
CAS Number
37326-33-3
Country of Origin
The raw animal product (bovine glands, organs and tissue) used in the manufacturing of Hyaluronidase is derived from materials of USDA-approved origin. It was collected in USDA or equivalent approved facilities and inspected to be free of disease.
Quality Control
SDS-PAGE
Unit Definition
One unit is based on the change in absorbency (turbidity) at 540nm of an internal standard.

Product Categories/Family for HYAL3 enzyme

Molecular Biology; MB-Enzymes; Glycosidase

Testing Data of HYAL3 enzyme

Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase; Hyaluronidase-1; Hyaluronoglucosaminidase-1, HYAL1, Hyal-1, EC=3.2.1.35, Hyaluronidase-2, Hyaluronoglucosaminidase-2, HYAL2, Hyal-2, EC=3.2.1.35, MGC126904
HYAL3 Enzyme – Cat# MBS653746

Testing Data of HYAL3 enzyme

Lane 1: MW standards|Lane 2: Reference Hyaluronidase, Bovine 25mg/ml|Lane 3: Hyaluronidase, Bovine lot# L11051258 5mg/ml|Lane 4: blank|Lane 5: Hyaluronidase, Bovine lot# L11051258 10mg/ml|Lane 6: blank|Lane 7: Hyaluronidase, Bovine lot# L11051258 25mg/ml|Lane 8: blank|Lane 9: MW standards|MW standards (kD): 97.5, 66, 45, 31, 21.5, 14.4
HYAL3 Enzyme, Testing Data – Cat# MBS653746

Testing Data of HYAL3 enzyme

HYAL3 Enzyme, Testing Data – Cat# MBS653746

Other Notes

Small volumes of HYAL3 enzyme vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HYAL3 purchase

MBS653746 is an enzyme targeting HYAL3. Also known as Hyaluronidase, Bovine, Highly Purified. Host: Bovine testes.

Additional Details

NCBI/Uniprot data below describe general gene information for HYAL3. It may not necessarily be applicable to this product.

NCBI GI #
2935328
NCBI GeneID
8372
NCBI Accession #
AAC70915.1
UniProt Primary Accession #
O43820
UniProt Secondary Accession #
O60540; Q8NFK2; Q8NFK3; Q8NFK4; Q96E56; Q9BRW9
UniProt Related Accession #
O43820
NCBI Official Full Name
hyaluronidase
NCBI Official Synonym Full Names
hyaluronoglucosaminidase 3
NCBI Official Symbol
HYAL3
NCBI Official Synonym Symbols
LUCA3; HYAL-3; LUCA-3
UniProt Protein Name
Hyaluronidase-3
UniProt Synonym Protein Names
Hyaluronoglucosaminidase-3; Lung carcinoma protein 3
UniProt Gene Name
HYAL3
UniProt Synonym Gene Names
LUCA3; Hyal-3; LuCa-3
UniProt Entry Name
HYAL3_HUMAN
NCBI Protein Information
hyaluronidase-3; lung carcinoma protein 3

NCBI Summary for HYAL3

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]
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UniProt Comments for HYAL3

Catalytic activity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Subcellular location: Secreted

By similarity. Lysosome

By similarity.

Tissue specificity: Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells. Ref.1 Ref.2

Sequence similarities: Belongs to the glycosyl hydrolase 56 family.Contains 1 EGF-like domain.

Sequence caution: The sequence AAC70915.1 differs from that shown. Reason: Frameshift at position 410.
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Research Articles on HYAL3

1. mutations of the HYAL3 gene are rare in Chinese lung squamous cell carcinoma patients and might contribute to lymph node metastasis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HYAL3 enzyme

 Reference Product  PubMed Publications
 IFRD2 enzyme  >1 publications with HYAL3 and IFRD2

Pathways associated with HYAL3 enzyme

 Products by Pathway  Pathway Diagram
 Chondroitin Sulfate Degradation Pathway antibodies  Chondroitin Sulfate Degradation Pathway Diagram
 Chondroitin Sulfate Degradation Pathway antibodies  Chondroitin Sulfate Degradation Pathway Diagram
 Dermatan Sulfate Degradation Pathway antibodies  Dermatan Sulfate Degradation Pathway Diagram
 Dermatan Sulfate Degradation Pathway antibodies  Dermatan Sulfate Degradation Pathway Diagram
 Glycosaminoglycan Degradation Pathway antibodies  Glycosaminoglycan Degradation Pathway Diagram
 Glycosaminoglycan Degradation Pathway antibodies  Glycosaminoglycan Degradation Pathway Diagram

Diseases associated with HYAL3 enzyme

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with HYAL3 and Disease Models, Animal
 Necrosis Antibodies  >2 publications with HYAL3 and Necrosis
 Genital Diseases, Male Antibodies  >1 publications with HYAL3 and Genital Diseases, Male
 Liver Neoplasms Antibodies  >1 publications with HYAL3 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with HYAL3 and Kidney Diseases
 Inflammation Antibodies  >1 publications with HYAL3 and Inflammation

Organs/Tissues associated with HYAL3 enzyme

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with HYAL3 and Lung
 Kidney Antibodies  >4 publications with HYAL3 and Kidney
 Blood Antibodies  >3 publications with HYAL3 and Blood
 Placenta Antibodies  >2 publications with HYAL3 and Placenta
 Embryonic Tissue Antibodies  >2 publications with HYAL3 and Embryonic Tissue
 Testis Antibodies  >1 publications with HYAL3 and Testis
 Brain Antibodies  >1 publications with HYAL3 and Brain
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