P-Selectin Glycoprotein Ligand 1 (PSGL-1) ELISA Kit for Goat

Name: Goat PSGL-1 ELISA Kit; P-Selectin Glycoprotein Ligand 1; MyBioSource
Brand: MyBioSource
SKU: MBS006543
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS006543

MBS006543 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the P-Selectin Glycoprotein Ligand 1 (PSGL-1) ELISA Kit target analytes in biological samples. The concentration gradients… More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

P-Selectin Glycoprotein Ligand 1 (PSGL-1), ELISA Kit

Full Product Name

Goat P-Selectin Glycoprotein Ligand 1 ELISA Kit

Product Gene Name

PSGL-1 elisa kit

Species Reactivity

Goat

Assay Type

Sandwich

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

43,201 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (109015671..109027670, complement). Location: 12q24

OMIM

600738

3D Structure

ModBase 3D Structure for Q14242

Other Notes

Small volumes of PSGL-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PSGL-1. It may not necessarily be applicable to this product.

NCBI GI #

331284238

NCBI GeneID

6404

NCBI Accession #

NP_001193538.1

UniProt Primary Accession #

Q14242

UniProt Secondary Accession #

Q12775; Q6GTW7; Q8N7J7; A8K2Y0; B4DQC3; B7Z5C7; J3KMX6

UniProt Related Accession #

Q14242

GenBank Nucleotide #

NM_001206609.1

NCBI Official Full Name

P-selectin glycoprotein ligand 1 isoform 1

NCBI Official Synonym Full Names

selectin P ligand

NCBI Official Symbol

SELPLG

NCBI Official Synonym Symbols

CLA; CD162; PSGL1; PSGL-1

UniProt Protein Name

P-selectin glycoprotein ligand 1

UniProt Synonym Protein Names

Selectin P ligand

Protein Family

P-selectin glycoprotein ligand

UniProt Gene Name

SELPLG

UniProt Synonym Gene Names

PSGL-1

UniProt Entry Name

SELPL_HUMAN

NCBI Protein Information

P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen

NCBI Summary for PSGL-1

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

UniProt Comments for PSGL-1

SELPLG: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor binding

Biological Process: blood coagulation; leukocyte tethering or rolling; cell adhesion; leukocyte migration; leukocyte adhesive activation

Research Articles on PSGL-1

1. The aim of the study was to investigate the degree of platelet activation in NSCLC and the roles of PSGL-1 in the activation of platelets.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PSGL-1 elisa kit

Reference Product	PubMed Publications
SELP elisa kit	>5 publications with PSGL-1 and SELP
SYK elisa kit	>1 publications with PSGL-1 and SYK

Pathways associated with PSGL-1 elisa kit

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Staphylococcus Aureus Infection Pathway antibodies	Staphylococcus Aureus Infection Pathway Diagram
Staphylococcus Aureus Infection Pathway antibodies	Staphylococcus Aureus Infection Pathway Diagram
Amb2 Integrin Signaling Pathway antibodies	Amb2 Integrin Signaling Pathway Diagram

Diseases associated with PSGL-1 elisa kit

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>6 publications with PSGL-1 and Cardiovascular Diseases
Atherosclerosis Antibodies	>4 publications with PSGL-1 and Atherosclerosis
Neoplasms Antibodies	>2 publications with PSGL-1 and Neoplasms
Congenital Abnormalities Antibodies	>1 publications with PSGL-1 and Congenital Abnormalities
Hypertension Antibodies	>1 publications with PSGL-1 and Hypertension
Drug Toxicity Antibodies	>1 publications with PSGL-1 and Drug Toxicity
Diabetes Mellitus, Type 2 Antibodies	>1 publications with PSGL-1 and Diabetes Mellitus, Type 2
Myocardial Infarction Antibodies	>1 publications with PSGL-1 and Myocardial Infarction
Inflammation Antibodies	>1 publications with PSGL-1 and Inflammation
Necrosis Antibodies	>1 publications with PSGL-1 and Necrosis

Organs/Tissues associated with PSGL-1 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>10 publications with PSGL-1 and Blood
Bone Antibodies	>2 publications with PSGL-1 and Bone
Heart Antibodies	>2 publications with PSGL-1 and Heart
Bone Marrow Antibodies	>2 publications with PSGL-1 and Bone Marrow
Placenta Antibodies	>2 publications with PSGL-1 and Placenta
Embryonic Tissue Antibodies	>2 publications with PSGL-1 and Embryonic Tissue
Lung Antibodies	>1 publications with PSGL-1 and Lung
Spleen Antibodies	>1 publications with PSGL-1 and Spleen
Brain Antibodies	>1 publications with PSGL-1 and Brain