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Neuron-Specific Enolase (NSE) Antibody – Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS660227

MBS660227 is an antibody targeting NSE. Also known as Monoclonal mouse anti-neuron specific enolase (NSE). More details

$610 / 1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neuron-Specific Enolase (NSE), Monoclonal Antibody
Full Product Name
Monoclonal mouse anti-neuron specific enolase (NSE)
Product Gene Name
anti-NSE antibody
Clonality
Monoclonal
Isotype
IgG2a for MAbs 5E2, 1C1, 5A4, H11 and 2F1
IgG2b for MAb 5G10
Clone Number
5G10, 5E2, 5A4, 1C1, H11, 2F1
Form/Format
PBS, pH 7.4, 0.1 % sodium azide (NaN3)
Purity/Purification
Chromatography on protein G Sepharose
Specificity
Human NSE
Preparation and Storage
4 degree C
Molecular Weight
47,141 Da
Clone Note
Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with purified NSE from human brain.
Applications Tested/Suitable for anti-NSE antibody
ELISA (EIA)
Application Notes for anti-NSE antibody
All MAbs work in ELISA. Recommended pairs for sandwich immunoassay (capture - detection):
5G10 - 1C1
5E2 - 1C1
1C1 - 5E2
5A4 - 1C1
H11 - 2F1

Other Notes

Small volumes of anti-NSE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NSE. It may not necessarily be applicable to this product.

NCBI GI #
204042
NCBI GeneID
24334
NCBI Accession #
AAA41119.1
UniProt Related Accession #
P07323
NCBI Official Full Name
neuron-specific enolase
NCBI Official Synonym Full Names
enolase 2, gamma, neuronal
NCBI Official Symbol
Eno2
NCBI Official Synonym Symbols
NSE; RNEN3
UniProt Protein Name
Gamma-enolase
UniProt Synonym Protein Names
2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE
Protein Family
Gamma-enolase
UniProt Gene Name
Eno2
UniProt Synonym Gene Names
Eno-2; NSE
UniProt Entry Name
ENOG_RAT
NCBI Protein Information
gamma-enolase; neural enolase; neuron-specific enolase; 2-phospho-D-glycerate hydro-lyase

NCBI Summary for NSE

catalyzes the interconversion of 2-phosphoglycerate to phosphoenolpyruvate; may play a role in glycolysis [RGD, Feb 2006]

UniProt Comments for NSE

ENO2: an enzyme with 2-phospho-D-glycerate hydro-lyase activity. One of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.

Protein type: EC 4.2.1.11; Lyase; Carbohydrate Metabolism - glycolysis and gluconeogenesis

Cellular Component: extracellular space; neuron projection; photoreceptor inner segment; phosphopyruvate hydratase complex; cell soma; cytoplasm; perikaryon; intracellular; myelin sheath

Molecular Function: protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; phosphopyruvate hydratase activity

Biological Process: response to drug; glycolysis; response to organic cyclic substance; response to estradiol stimulus; gluconeogenesis
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Research Articles on NSE

1. Hyperglycemia may impair mitochondrial function and alter glycolysis in glomerular epithelial cells by down-regulating the expression of ATP synthase beta subunit and enolase 2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NSE antibody

 Reference Product  PubMed Publications
 Aldoc antibody  >3 publications with NSE and Aldoc
 Pck1 antibody  >3 publications with NSE and Pck1
 Gpi antibody  >2 publications with NSE and Gpi
 Pkm2 antibody  >2 publications with NSE and Pkm2
 Aldoa antibody  >1 publications with NSE and Aldoa
 Pklr antibody  >1 publications with NSE and Pklr

Pathways associated with anti-NSE antibody

 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram

Diseases associated with anti-NSE antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >8 publications with NSE and Disease Models, Animal
 Nervous System Diseases Antibodies  >7 publications with NSE and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with NSE and Brain Diseases
 Adenocarcinoma Antibodies  >4 publications with NSE and Adenocarcinoma
 Kidney Diseases Antibodies  >3 publications with NSE and Kidney Diseases
 Inflammation Antibodies  >2 publications with NSE and Inflammation
 Prostatic Neoplasms Antibodies  >2 publications with NSE and Prostatic Neoplasms
 Hypertension Antibodies  >2 publications with NSE and Hypertension
 Lung Diseases Antibodies  >2 publications with NSE and Lung Diseases
 Neoplasms, Experimental Antibodies  >2 publications with NSE and Neoplasms, Experimental

Organs/Tissues associated with anti-NSE antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with NSE and Brain
 Embryonic Tissue Antibodies  >3 publications with NSE and Embryonic Tissue
 Nerve Antibodies  >3 publications with NSE and Nerve
 Heart Antibodies  >2 publications with NSE and Heart
 Prostate Antibodies  >2 publications with NSE and Prostate
 Eye Antibodies  >2 publications with NSE and Eye
 Ovary Antibodies  >1 publications with NSE and Ovary
 Connective Tissue Antibodies  >1 publications with NSE and Connective Tissue
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