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CD79a Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS666033

Information: Human CD79a is a 22kd glycoprotein which associates with CD79b to form a functional heterodimer that interacts with membrane immunoglobulin (mIg).The mIgM component binds antigen and the heterodimer transduces signals. Antibody ZL7-4 recognizes… More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD79a, Monoclonal Antibody
Full Product Name
anti-human CD79a-Purified (with Antibiotics)
Product Gene Name
anti-CD79a antibody
Product Synonym Names
Monoclonal anti-human CD79a(mb1)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
ZL7-4
Host
Mouse
Species Reactivity
Human
Form/Format
50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate
Purity/Purification
Purified (with Antibiotics)
Concentration
1.0 mg/ml (lot specific)
Preparation and Storage
Store at 2 - 5 degree C. Freeze/Thawing is not recommended.
Product should retain activity for at least 12 months after shipping date when stored as recommended.
Molecular Weight
20,786 Da
OMIM
613501
Performance
Five x 105 cultured human Daudi cells were pre incubated 5 minutes with 20 mul of 250 mug/ml human Ig (to block non specific binding) after which they were incubated 45 minutes on ice with 80 mul of anti-CD79a antibody at 10 mug/ml. Cells were washed twice and incubated with 2 degree reagent Goat anti-Mouse IgG/FITC, after which they were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 1.02 log10 fluorescent units when compared to a Mouse IgG1 negative control at a similar concentration.
Production
Antibody was Protein A purified from (low FBS containing) tissue culture supernatant. Purity was >95% Immunoglobulin by SDS-PAGE with less than 1% Bovine Immunoglobulin.
Buffer
50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5 mg/ml Gentamicin Sulfate (as a preservative).
Group Header
anti-human CD79a
Immunogen
Daudi IgM complex
Applications Tested/Suitable for anti-CD79a antibody
Flow Cytometry (FC/FACS)

Testing Data of anti-CD79a antibody

Mouse Anti-CD79a Monoclonal Antibody – Cat# MBS666033

Product References and Citations for anti-CD79a antibody

1) L. Zhang, M.J. Glennie, et al. (1995) Therapeutic Immunol. 2: 191-202. 2) Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 180-185. 3) Chu PG, Arber DA. (2001) Appl Immunohistochem Molecul Morphol 9: 97-106.

Other Notes

Small volumes of anti-CD79a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD79a purchase

MBS666033 is an antibody targeting CD79a. Also known as anti-human CD79a-Purified (with Antibiotics). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD79a. It may not necessarily be applicable to this product.

NCBI GI #
1087007
NCBI GeneID
973
NCBI Accession #
AAC60653.1
UniProt Secondary Accession #
Q53FB8; A0N775
UniProt Related Accession #
P11912
NCBI Official Full Name
CD79a, partial
NCBI Official Synonym Full Names
CD79a molecule, immunoglobulin-associated alpha
NCBI Official Symbol
CD79A
NCBI Official Synonym Symbols
IGA; MB-1
UniProt Protein Name
B-cell antigen receptor complex-associated protein alpha chain
UniProt Synonym Protein Names
Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD_antigen: CD79a
Protein Family
B-cell antigen receptor complex-associated protein
UniProt Gene Name
CD79A
UniProt Synonym Gene Names
IGA; MB1
UniProt Entry Name
CD79A_HUMAN
NCBI Protein Information
B-cell antigen receptor complex-associated protein alpha chain; ig-alpha; MB-1 membrane glycoprotein; surface IgM-associated protein; CD79a antigen (immunoglobulin-associated alpha); membrane-bound immunoglobulin-associated protein

NCBI Summary for CD79a

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD79a

Ig-alpha: an integral membrane protein that associates with surface immunoglobulin B lymphocyte antigen receptor multimeric complex. Surface Ig non-covalently associates with 2 other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: multivesicular body; integral to membrane; plasma membrane; B cell receptor complex; lipid raft; external side of plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: B cell proliferation; B cell receptor signaling pathway; B cell activation; B cell differentiation

Disease: Agammaglobulinemia 3, Autosomal Recessive
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Research Articles on CD79a

1. CD79a plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD79a antibody

 Reference Product  PubMed Publications
 CD79B antibody  >614 publications with CD79a and CD79B
 CD19 antibody  >150 publications with CD79a and CD19
 PTPRC antibody  >85 publications with CD79a and PTPRC
 CD22 antibody  >68 publications with CD79a and CD22
 SYK antibody  >35 publications with CD79a and SYK
 LYN antibody  >26 publications with CD79a and LYN
 BLNK antibody  >12 publications with CD79a and BLNK
 FYN antibody  >10 publications with CD79a and FYN
 BLK antibody  >5 publications with CD79a and BLK

Pathways associated with anti-CD79a antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Signaling By The B Cell Receptor (BCR) Pathway antibodies  Signaling By The B Cell Receptor (BCR) Pathway Diagram

Diseases associated with anti-CD79a antibody

 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >719 publications with CD79a and Lymphoma
 Leukemia Antibodies  >265 publications with CD79a and Leukemia
 Skin Neoplasms Antibodies  >84 publications with CD79a and Skin Neoplasms
 Neoplasms, Experimental Antibodies  >76 publications with CD79a and Neoplasms, Experimental
 Inflammation Antibodies  >45 publications with CD79a and Inflammation
 Liver Diseases Antibodies  >42 publications with CD79a and Liver Diseases
 Necrosis Antibodies  >40 publications with CD79a and Necrosis
 Hyperplasia Antibodies  >39 publications with CD79a and Hyperplasia
 Lung Diseases Antibodies  >37 publications with CD79a and Lung Diseases
 Liver Neoplasms Antibodies  >29 publications with CD79a and Liver Neoplasms

Organs/Tissues associated with anti-CD79a antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >574 publications with CD79a and Blood
 Lymph Node Antibodies  >222 publications with CD79a and Lymph Node
 Lymph Antibodies  >207 publications with CD79a and Lymph
 Spleen Antibodies  >89 publications with CD79a and Spleen
 Liver Antibodies  >83 publications with CD79a and Liver
 Lung Antibodies  >54 publications with CD79a and Lung
 Intestine Antibodies  >45 publications with CD79a and Intestine
 Thymus Antibodies  >31 publications with CD79a and Thymus
 Heart Antibodies  >26 publications with CD79a and Heart
 Mouth Antibodies  >22 publications with CD79a and Mouth
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