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CD19 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS666337

Information: Human CD19 is a B cell restricted membrane protein expressed from early stages of B cell development and associates with the antigen receptor complex. CD19 is involved in the regulation of B cell proliferation but eventually disappears from… More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD19, Monoclonal Antibody
Full Product Name
anti-human CD19-Purified Preservative Free
Product Gene Name
anti-CD19 antibody
Product Synonym Names
Monoclonal anti-human CD19
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BU12
Host
Mouse
Species Reactivity
Human
Form/Format
50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl
Purity/Purification
Purified Preservative Free
Concentration
1.0 mg/ml (lot specific)
Preparation and Storage
Store at 2 - 5 degree C. Open under aseptic conditions. Freeze/Thawing is not recommended.
Product should retain activity for at least 12 months after shipping date when stored as recommended.
Molecular Weight
61,200 Da
OMIM
613493
Performance
Five x 105 cultured Raji cells were washed and incubated 45 minutes on ice with 80 ul of anti-CD19 antibody at 10 ug/ml. Cells were washed twice and incubated with 2 degree reagent Goat anti-Mouse IgG/FITC, after which they were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 1.7 log10 fluorescent units when compared to a Mouse IgG1 negative control at a similar concentration.
Production
Antibody was Protein A purified from (low FBS containing) tissue culture supernatant. Purity was >95% Immunoglobulin by SDS-PAGE and contains less than 1% Bovine Immunoglobulin. Product was 0.2 um filtered and vialed under aseptic conditions.
Buffer
50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl.
Immunogen
Human EB-4 Burkitt lymphoma cell line
Applications Tested/Suitable for anti-CD19 antibody
Flow Cytometry (FC/FACS)

Testing Data of anti-CD19 antibody

Mouse Anti-CD19 Monoclonal Antibody – Cat# MBS666337

Product References and Citations for anti-CD19 antibody

D.T. Fearon & R.H. Carter, (1995) Annu Rev Immunol 13: 127-149. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 507-511. S. Behr & F. Schriever, (1995) J Exp Med 182: 1191-1199.

Other Notes

Small volumes of anti-CD19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD19 purchase

MBS666337 is an antibody targeting CD19. Also known as anti-human CD19-Purified Preservative Free. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD19. It may not necessarily be applicable to this product.

NCBI GI #
4105281
NCBI GeneID
930
NCBI Accession #
AAD02340.1
UniProt Secondary Accession #
Q96S68; Q9BRD6; A0N0P9; F5H635
UniProt Related Accession #
P15391
NCBI Official Full Name
CD19, partial
NCBI Official Synonym Full Names
CD19 molecule
NCBI Official Symbol
CD19
NCBI Official Synonym Symbols
B4; CVID3
UniProt Protein Name
B-lymphocyte antigen CD19
UniProt Synonym Protein Names
B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19
Protein Family
B-lymphocyte antigen
UniProt Gene Name
CD19
UniProt Entry Name
CD19_HUMAN
NCBI Protein Information
B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4

NCBI Summary for CD19

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD19

CD19: a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: protein complex; integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: receptor signaling protein activity

Biological Process: epidermal growth factor receptor signaling pathway; regulation of immune response; B cell receptor signaling pathway; cell surface receptor linked signal transduction; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; cellular defense response; innate immune response; positive regulation of release of sequestered calcium ion into cytosol

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 3
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Research Articles on CD19

1. A lower primary CD24(hi) CD27(+) CD19(+) B cells may be an immunologic aspect of new-onset SLE that may be a useful tool to evaluate lupus activity and monitor the response to therapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD19 antibody

 Reference Product  PubMed Publications
 CD22 antibody  >598 publications with CD19 and CD22
 CD79A antibody  >150 publications with CD19 and CD79A
 CD79B antibody  >107 publications with CD19 and CD79B
 CD81 antibody  >96 publications with CD19 and CD81
 CR2 antibody  >75 publications with CD19 and CR2
 LYN antibody  >57 publications with CD19 and LYN
 SYK antibody  >46 publications with CD19 and SYK
 BTK antibody  >42 publications with CD19 and BTK
 VAV1 antibody  >13 publications with CD19 and VAV1

Pathways associated with anti-CD19 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram

Diseases associated with anti-CD19 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >436 publications with CD19 and Cardiovascular Diseases
 Inflammation Antibodies  >354 publications with CD19 and Inflammation
 Respiratory Tract Diseases Antibodies  >324 publications with CD19 and Respiratory Tract Diseases
 Necrosis Antibodies  >317 publications with CD19 and Necrosis
 Death Antibodies  >259 publications with CD19 and Death
 Lung Diseases Antibodies  >204 publications with CD19 and Lung Diseases
 Liver Diseases Antibodies  >161 publications with CD19 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >136 publications with CD19 and Cell Transformation, Neoplastic
 Respiratory Tract Infections Antibodies  >110 publications with CD19 and Respiratory Tract Infections
 Asthma Antibodies  >93 publications with CD19 and Asthma

Organs/Tissues associated with anti-CD19 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6135 publications with CD19 and Blood
 Bone Marrow Antibodies  >1719 publications with CD19 and Bone Marrow
 Spleen Antibodies  >566 publications with CD19 and Spleen
 Lymph Node Antibodies  >469 publications with CD19 and Lymph Node
 Lymph Antibodies  >419 publications with CD19 and Lymph
 Lung Antibodies  >213 publications with CD19 and Lung
 Thymus Antibodies  >171 publications with CD19 and Thymus
 Brain Antibodies  >131 publications with CD19 and Brain
 Tonsil Antibodies  >116 publications with CD19 and Tonsil
 Intestine Antibodies  >104 publications with CD19 and Intestine
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