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CD127 Human Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS666848

Information: CD127 (IL-7Ra) is the specific receptor component for the cytokine Interleukin -7 (IL-7). It is found on a wide variety of hematopoietic cell types including B cell precursors, and the majority of T cells. Its expression levels are decreased on T… More details

$605 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD127, Protein
Full Product Name
CD127-muIg-Purified (with Antibiotics)
Product Gene Name
CD127 protein
Product Synonym Names
Human CD127(IL-7Ra)-muIg Fusion Protein
Sequence
(1)kpqapel rgs(10) th e mature extracellu lar domain of human CD127 (IL-7Ra): (11)esgyaq ngdledaeld dysfscysql evngsqhslt cafedpdvni tnlefeicga lvevkclnfr klqeiyfiet kkflligksn icvkvgeksl tckkidltti vkpeapfdls vvyregandf vtfntshlqk kyvkvlmhdv ayrqekdenk wthvnlsstk ltllqrklqp aamyeikvrs ipdhyfkgfw sewspsyyfr tpeinnssge md(229) mu rine IgG2a Fc + hinge regions: (230)gtepr gptikpcppc kcpapnllgg psvfifppki kdvlmislsp ivtcvvvdvs eddpdvqisw fvnnvevhta qtqthredyn stlrvvsalp iqhqdwmsgk efkckvnnkd lpapiertis kpgsvrapqv yvlpppeeem tkkqvtltcm vtdfmpediy vewtnngkte lnykntepvl dsdgsyfmys klrvekknwv ernsyscsvv heglhnhhtt ksfsrtpgk( 464) (464 aa total). The molecule is dimeric with a predicted monomeric non glycosylat ed molecular weight of 52.8 kd.
Host
CHO cells
Species Reactivity
Human
Form/Format
50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate
Purity/Purification
Purified (with Antibiotics)
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
Store at 2 - 5 degree C. Freeze/Thawing is not recommended.
Product should retain activity for at least 12 months after shipping date when stored as recommended.
Molecular Weight
51,365 Da
3D Structure
ModBase 3D Structure for B9ZSM5
Transfectant Cell Line
CHO
Performance
Recombinant soluble CD127-muIg was reactive with anti-CD127 clone 40131 as well as clone ANC8F2 in EIA and FACS.
Production
Human CD127-muIg fusion protein was Protein A purified from (low FBS containing) tissue culture supernatant of CHO transfectants.
Buffer
50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5 mg/ml Gentamicin sulfate (as a preservative).
Group Header
CD127-muIg
Applications Tested/Suitable for CD127 protein
ELISA (EIA)

Product References and Citations for CD127 protein

1) Noguchi, M. et al., 1993, Science 262:1877. 2) Pribyl, J.A. and T.W. LeBien, 1996, Proc. Natl. Acad. Sci. 93:10348. 3) Goodwin RG, Friend D, Ziegler SF, et al. Cell. 1990;60:941.

Other Notes

Small volumes of CD127 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD127 purchase

MBS666848 is a protein targeting CD127. Also known as CD127-muIg-Purified (with Antibiotics). Reactive in Human. Host: CHO cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD127. It may not necessarily be applicable to this product.

NCBI GI #
224697002
NCBI GeneID
100271930
NCBI Accession #
CAM57334.1
UniProt Primary Accession #
B9ZSM5
NCBI Official Full Name
CD127 protein
NCBI Official Symbol
IL7R
NCBI Official Synonym Symbols
CD127
UniProt Protein Name
CD127 protein
UniProt Synonym Protein Names
CD127 protein
Protein Family
Interleukin-7 receptor
UniProt Gene Name
CD127
UniProt Entry Name
B9ZSM5_PIG
NCBI Protein Information
interleukin-7 receptor subunit alpha

Research Articles on CD127

1. Expression analysis indicates that the mRNA transcript of pig CD127 is mainly detected in lymphoid tissues, but still detected in nonlymphoid tissues

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD127 protein

 Reference Product  PubMed Publications
 IL7 protein  >12 publications with CD127 and IL7
 JAK3 protein  >9 publications with CD127 and JAK3
 IL2RG protein  >8 publications with CD127 and IL2RG
 JAK2 protein  >5 publications with CD127 and JAK2
 JAK1 protein  >5 publications with CD127 and JAK1
 TYK2 protein  >3 publications with CD127 and TYK2

Pathways associated with CD127 protein

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-7 Signaling Pathway antibodies  Interleukin-7 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with CD127 protein

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >69 publications with CD127 and Immune System Diseases
 Multiple Sclerosis Antibodies  >30 publications with CD127 and Multiple Sclerosis
 Inflammation Antibodies  >17 publications with CD127 and Inflammation
 Necrosis Antibodies  >11 publications with CD127 and Necrosis
 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >7 publications with CD127 and Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
 Disease Models, Animal Antibodies  >6 publications with CD127 and Disease Models, Animal
 Liver Diseases Antibodies  >5 publications with CD127 and Liver Diseases
 Lung Diseases Antibodies  >4 publications with CD127 and Lung Diseases
 Hypersensitivity Antibodies  >4 publications with CD127 and Hypersensitivity
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >3 publications with CD127 and Encephalomyelitis, Autoimmune, Experimental

Organs/Tissues associated with CD127 protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >81 publications with CD127 and Blood
 Thymus Antibodies  >14 publications with CD127 and Thymus
 Liver Antibodies  >7 publications with CD127 and Liver
 Spleen Antibodies  >5 publications with CD127 and Spleen
 Lymph Antibodies  >4 publications with CD127 and Lymph
 Lymph Node Antibodies  >4 publications with CD127 and Lymph Node
 Intestine Antibodies  >3 publications with CD127 and Intestine
 Muscle Antibodies  >1 publications with CD127 and Muscle
 Trachea Antibodies  >1 publications with CD127 and Trachea
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